Zhang Li, Hu Zhigang, Li Zhenxing, Lin Yixing
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.
Neural Regen Res. 2024 Aug 1;19(8):1660-1670. doi: 10.4103/1673-5374.389361. Epub 2023 Nov 8.
Central nervous system injuries have a high rate of resulting in disability and mortality; however, at present, effective treatments are lacking. Programmed cell death, which is a genetically determined form of active and ordered cell death with many types, has recently attracted increasing attention due to its functions in determining the fate of cell survival. A growing number of studies have suggested that programmed cell death is involved in central nervous system injuries and plays an important role in the progression of brain damage. In this review, we provide an overview of the role of programmed cell death in central nervous system injuries, including the pathways involved in mitophagy, pyroptosis, ferroptosis, and necroptosis, and the underlying mechanisms by which mitophagy regulates pyroptosis, ferroptosis, and necroptosis. We also discuss the new direction of therapeutic strategies targeting mitophagy for the treatment of central nervous system injuries, with the aim to determine the connection between programmed cell death and central nervous system injuries and to identify new therapies to modulate programmed cell death following central nervous system injury. In conclusion, based on these properties and effects, interventions targeting programmed cell death could be developed as potential therapeutic agents for central nervous system injury patients.
中枢神经系统损伤导致残疾和死亡的比例很高；然而，目前缺乏有效的治疗方法。程序性细胞死亡是一种由基因决定的、具有多种类型的主动且有序的细胞死亡形式，由于其在决定细胞存活命运方面的功能，近来受到越来越多的关注。越来越多的研究表明，程序性细胞死亡与中枢神经系统损伤有关，并且在脑损伤的进展中起重要作用。在这篇综述中，我们概述了程序性细胞死亡在中枢神经系统损伤中的作用，包括与线粒体自噬、细胞焦亡、铁死亡和坏死性凋亡相关的途径，以及线粒体自噬调节细胞焦亡、铁死亡和坏死性凋亡的潜在机制。我们还讨论了针对线粒体自噬治疗中枢神经系统损伤的治疗策略的新方向，目的是确定程序性细胞死亡与中枢神经系统损伤之间的联系，并确定在中枢神经系统损伤后调节程序性细胞死亡的新疗法。总之，基于这些特性和作用，针对程序性细胞死亡的干预措施可被开发为中枢神经系统损伤患者的潜在治疗药物。
