Mannheimer Clas, Carlsson Carl-Axel, Vedin Anders, Wilhelmsson Clas
Pain Section, Department of Medicine, Östra Hospital, S-416 85 GöteborgSweden Department of Neurosurgery, Sahlgrenska Hospital, S-413 45 GöteborgSweden.
Pain. 1986 Sep;26(3):291-300. doi: 10.1016/0304-3959(86)90058-8.
The aim of this study was to determine the efficacy of transcutaneous electrical nerve stimulation (TENS) in the treatment of chronic stable severe angina pectoris. In a short-term study the effect of TENS was studied in 10 male patients with angina pectoris (functional class III and IV). All patients had previously been stabilized on long-term maximal oral treatment. The effects of the treatment were measured by means of repeated bicycle ergometer tests. All patients had an increased working capacity (16-85%), decreased ST segment depression and reduced recovery time during TENS. No adverse effects were observed. A long-term study of TENS on similarly selected patients showed beneficial effects in terms of pain reduction, reduced frequency of anginal attacks, increased physical activity and increased working capacity during bicycle ergometer tests. An invasive study was carried out with respect to systemic and coronary hemodynamics and myocardial metabolism during pacing provoked myocardial ischemia in 13 patients. The results showed that TENS led to an increased tolerance to pacing, improved lactate metabolism, less pronounced ST segment depression. A drop in systolic blood pressure during TENS treatment at identical pacing rates indicated a decreased afterload. An increased coronary flow to ischemic areas in the myocardium was supported by the fact that the rate pressure product during anginal pain increased during TENS.
本研究的目的是确定经皮电刺激神经疗法(TENS)治疗慢性稳定型重度心绞痛的疗效。在一项短期研究中,对10名心绞痛男性患者(功能分级为III级和IV级)进行了TENS疗效研究。所有患者此前均已通过长期最大剂量口服治疗实现病情稳定。通过重复进行自行车测力计测试来衡量治疗效果。在进行TENS治疗期间,所有患者的工作能力均有所提高(提高了16%至85%),ST段压低减轻,恢复时间缩短。未观察到不良反应。对类似选择的患者进行的TENS长期研究表明,在减轻疼痛、减少心绞痛发作频率、增加体力活动以及在自行车测力计测试中提高工作能力方面均有有益效果。对13名患者在起搏诱发心肌缺血期间的全身和冠状动脉血流动力学以及心肌代谢进行了侵入性研究。结果表明,TENS使起搏耐受性增加,改善了乳酸代谢,ST段压低不那么明显。在相同起搏频率下进行TENS治疗期间收缩压下降表明后负荷降低。TENS期间心绞痛发作时心率血压乘积增加,这一事实支持了心肌缺血区域冠状动脉血流量增加的观点。