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黑腹果蝇中宏量营养素耐受性的遗传变异。

Genetic variation of macronutrient tolerance in Drosophila melanogaster.

机构信息

Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.

School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia.

出版信息

Nat Commun. 2022 Mar 28;13(1):1637. doi: 10.1038/s41467-022-29183-x.

DOI:10.1038/s41467-022-29183-x
PMID:35347148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8960806/
Abstract

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.

摘要

碳水化合物、蛋白质和脂质是所有动物必需的营养物质；然而，密切相关的物种、种群和个体在饮食上可能表现出显著的差异。在这里，我们利用果蝇遗传参考面板（一个由源自单一自然种群的~200 个品系组成的集合）来探索黑腹果蝇在宏量营养素耐受性方面的变化。我们的研究表明，通常被认为是“杂食性”的黑腹果蝇在不同饮食条件下的生存能力存在显著的遗传变异，尤其是在高糖饮食条件下。我们的遗传分析和功能验证确定了几种调节宏量营养素耐受性的调节剂，包括 CG10960/GLUT8、Pkn 和 Eip75B。我们还证明了 JNK 途径在糖耐受性和从头脂肪生成中的作用。最后，我们报告了一个保守的孤儿核激素受体 tailless 在通过胰岛素样肽分泌和糖反应性 CCHamide-2 表达来调节糖代谢中的作用。我们的研究为个性化营养的营养基因组学的应用提供了支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/e9cb93b6fec6/41467_2022_29183_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/d301d4c8b907/41467_2022_29183_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/f3e29b832c1f/41467_2022_29183_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/a994dc4f4553/41467_2022_29183_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/ec4c06b48411/41467_2022_29183_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/b21e35fa133a/41467_2022_29183_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/6887283e5b47/41467_2022_29183_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/f256168cbfa2/41467_2022_29183_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/e9cb93b6fec6/41467_2022_29183_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/d301d4c8b907/41467_2022_29183_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/f3e29b832c1f/41467_2022_29183_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/a994dc4f4553/41467_2022_29183_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/ec4c06b48411/41467_2022_29183_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/b21e35fa133a/41467_2022_29183_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/6887283e5b47/41467_2022_29183_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/f256168cbfa2/41467_2022_29183_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e2e/8960806/e9cb93b6fec6/41467_2022_29183_Fig8_HTML.jpg

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