Auvergnat J C, Lemozy J, Lokiec F, Pecking M
Pathol Biol (Paris). 1986 May;34(5):508-11.
Following intravenous administration of 2 g ceftriaxone, concentrations of the drug were assayed in serum, in thoracic duct lymph from dogs, and in mesenteric lymph nodes in patients. Antibacterial activity of lymph against S. typhi was also studied. Results show that ceftriaxone concentrations in serum and lymph are comparable; with a satisfactory antibacterial activity of both fluids against S. typhi. In mesenteric lymph nodes, mean ceftriaxone concentration was approximately 1000 times the MIC for S. typhi. Our data contribute to explain the successful clinical results achieved with ceftriaxone in patients with typhoid fever.
静脉注射2克头孢曲松后，测定了血清、犬胸导管淋巴液及患者肠系膜淋巴结中该药物的浓度。还研究了淋巴液对伤寒杆菌的抗菌活性。结果显示，血清和淋巴液中的头孢曲松浓度相当；两种液体对伤寒杆菌均具有令人满意的抗菌活性。在肠系膜淋巴结中，头孢曲松的平均浓度约为伤寒杆菌最低抑菌浓度的1000倍。我们的数据有助于解释头孢曲松治疗伤寒热患者取得成功临床疗效的原因。
