College of Science, Huazhong Agricultural University, Wuhan, 430070, China.
College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, China.
Nanoscale Horiz. 2022 May 3;7(5):554-561. doi: 10.1039/d2nh00023g.
Generally, a high quality surface-enhanced Raman spectroscopy (SERS) substrate often requires a highly-tailorable electromagnetic (EM) field generated at nanoparticle (NP) surfaces by the regulation of the morphologies, components and roughness of NPs. However, most recent universal approaches are restricted to single components, and integrating these key factors into one system to achieve the theoretically maximum signal amplification is still challenging. Herein, we design a triple SERS signal amplification platform by the coordination of spiky Au NPs with rich-tip nanostructures, controllable silver nanoshell, as well as tailorable surface roughness into one nano-system. As a result, the theoretical electromagnetic field of the interfacial self-assembled 2D substrate can be improved by nearly 5 orders of magnitude, and the ideal tracing capability for the model SERS molecule can be achieved at levels of 5 × 10 M. Finally, diverse analytes in pesticide residues, environmental pollutants as well as medically diagnose down to 10 M and can be fingerprinted by the proposed SERS nano-platform. Our integrated triple amplification platform not only provides an effective SERS sensing strategy, but also makes it possible to simultaneously achieve high sensitivity, stability as well as universality into one plasmonic-based SERS sensing system.
通常，高质量的表面增强拉曼光谱（SERS）基底通常需要通过调节纳米粒子（NP）的形态、组成和粗糙度来在 NP 表面产生高度可调的电磁场。然而，大多数最新的通用方法仅限于单一成分，并且将这些关键因素集成到一个系统中以实现理论上最大的信号放大仍然具有挑战性。在此，我们通过将具有丰富尖端结构的刺状 Au NPs、可控的银纳米壳以及可调节的表面粗糙度协调到一个纳米系统中，设计了一个三重 SERS 信号放大平台。结果，界面自组装二维基底的理论电磁场可以提高近 5 个数量级，并且可以在 5×10^-6 M 的水平上实现对模型 SERS 分子的理想跟踪能力。最后，可以通过所提出的 SERS 纳米平台对农药残留、环境污染物以及医学诊断等各种分析物进行指纹识别，检测下限低至 10^-6 M。我们的集成三重放大平台不仅提供了一种有效的 SERS 传感策略，而且还可以将高灵敏度、稳定性和通用性同时集成到一个基于等离子体的 SERS 传感系统中。
