Wei Wen-Jiang, Tian Zuo-Fu, Liu Hao, Xiao Cheng-Jiang
Interventional Vascular Department, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, 466 Xingang Middle Road, Guangzhou, 510317, Guangdong, China.
College of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, 350122, Fujian, China.
Sci Rep. 2025 Feb 19;15(1):6027. doi: 10.1038/s41598-025-85823-4.
Uterine adenomyosis, a common benign tumor disease in gynecology, mainly manifested as chronic pelvic pain, menstrual disorders, dysmenorrhea, etc., has a great impact on patients' daily life and work. Compared with traditional surgery and drug therapy, uterine artery embolization (UAE), as a new treatment with less trauma, faster recovery and uterine preservation, can relieve pain while preserving normal physiological and reproductive functions of the uterus, which is favored by the majority of patients. In this study, the patients were divided into two groups based on magnetic resonance imaging (MRI) test. Their serum CA125 level was detected, and the degree of symptom relief and health index were evaluated, aiming to explore the clinical efficacy and influencing factors of UAE in the treatment of adenomyosis. The results showed that before UAE, CA125 level in group B was significantly higher than that in group A, and 2 days after UAE, CA125 level in both groups was lower than before treatment, indicating that the serum CA125 level may be related to the type of adenomyosis, but UAE has a good therapeutic effect on both focal and diffuse adenomyosis. 3 months after interventional treatment, the patients had significantly reduced symptoms with dramatically improved health status and the VAS pain score was significantly reduced, indicating that UAE can significantly improve the clinical symptoms of patients with adenomyosis. Uterine artery embolization was performed in both groups. No serious complications occurred during the operation, and the technical success rate reached 100%. In summary, UAE, as a minimally invasive treatment, has obvious and significant clinical effects in the treatment of adenomyosis, and is an important alternative treatment for adenomyosis.
子宫腺肌病是妇科常见的良性肿瘤疾病，主要表现为慢性盆腔疼痛、月经紊乱、痛经等，对患者的日常生活和工作有很大影响。与传统手术和药物治疗相比，子宫动脉栓塞术（UAE）作为一种创伤小、恢复快且能保留子宫的新型治疗方法，在缓解疼痛的同时可保留子宫的正常生理和生殖功能，受到广大患者青睐。在本研究中，根据磁共振成像（MRI）检查将患者分为两组。检测其血清CA125水平，并评估症状缓解程度和健康指数，旨在探讨UAE治疗腺肌病的临床疗效及影响因素。结果显示，UAE术前，B组CA125水平显著高于A组，UAE术后2天，两组CA125水平均低于治疗前，表明血清CA125水平可能与腺肌病类型有关，但UAE对局灶性和弥漫性腺肌病均有良好治疗效果。介入治疗3个月后，患者症状明显减轻，健康状况显著改善，视觉模拟评分（VAS）疼痛评分显著降低，表明UAE可显著改善腺肌病患者的临床症状。两组均进行了子宫动脉栓塞术。术中未发生严重并发症，技术成功率达100%。综上所述，UAE作为一种微创治疗方法，在治疗腺肌病方面具有明显且显著的临床效果，是腺肌病重要的替代治疗方法。
