Atherosclerosis Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
High Institute for Education and Research in Transfusion Medicine, Tehran, Iran.
Cardiovasc Toxicol. 2022 May;22(5):391-403. doi: 10.1007/s12012-022-09734-w. Epub 2022 Mar 28.
Preeclampsia (PE) is one of the complications, that threatens pregnant mothers during pregnancy. According to studies, it accounts for 3-7% of all pregnancies, and also is effective in preterm delivery. PE is the third leading cause of death in pregnant women. High blood pressure in PE can increase the risk of developing cardiovascular disease (CVD) in cited individuals, and is one of the leading causes of death in PE individuals. Atrial natriuretic peptide (ANP), Renin-Angiotensin system and nitric oxide (NO) are some of involved factors in regulating blood pressure. Therefore, by identifying the signaling pathways, that are used by these molecules to regulate and modulate blood pressure, appropriate treatment strategies can be provided to reduce blood pressure through target therapy in PE individuals; consequently, it can reduce CVD risk and mortality.
子痫前期(PE)是一种妊娠并发症,威胁着孕妇的健康。研究表明,PE 约占所有妊娠的 3-7%,并与早产密切相关。PE 是导致孕妇死亡的第三大原因。PE 患者的高血压会增加心血管疾病(CVD)的发病风险,也是导致 PE 患者死亡的主要原因之一。心钠肽(ANP)、肾素-血管紧张素系统和一氧化氮(NO)是调节血压的相关因子。因此,通过鉴定这些分子调节和控制血压的信号通路,通过靶向治疗为 PE 患者提供适当的治疗策略,以降低血压,从而降低 CVD 风险和死亡率。