Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.
Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
J Oral Pathol Med. 2022 May;51(5):413-420. doi: 10.1111/jop.13295. Epub 2022 Apr 11.
Fungi, a diverse group of eukaryotic organisms, play distinct roles in health and disease. Recent advances in the field of mycobiology have enabled the characterization of the "human mycobiome." The human mycobiome has extensively been studied in various disease models. However, to date, the role of the oral mycobiome in oral carcinogenesis has yet to be elucidated. Candida albicans, the most common oral colonizer, has been speculated to display tumorigenic effects; however, the literature lacks consistent documentation from mechanistic studies on whether oral mycobiota act as drivers, facilitators, or passive colonizers of oral premalignancy and cancer. This review article provides an overview of existing hypothesis-driven mechanistic models that outline the complex interplay between the oral mycobiome and oral epithelial dysplasia as well as their potential clinical implications.
真菌是一类多样化的真核生物，在健康和疾病中发挥着不同的作用。近年来，在真菌生物学领域的进展使得对“人类真菌组”的特征描述成为可能。人类真菌组在各种疾病模型中得到了广泛的研究。然而，迄今为止，口腔真菌组在口腔癌变中的作用尚未阐明。口腔定植最常见的真菌白色念珠菌被推测具有致癌作用；然而，文献缺乏关于口腔真菌群是否作为口腔癌前病变和癌症的驱动因素、促进因素或被动定植者的机制研究的一致性记录。本文综述了现有的假设驱动的机制模型，概述了口腔真菌组与口腔上皮异型增生之间的复杂相互作用及其潜在的临床意义。
