Department of Internal Medicine, Michigan State University - Sparrow Hospital, Lansing, MI.
Sparrow Thoracic and Cardiovascular Institute, Lansing, MI.
Perm J. 2021 May 12;25:21.006. doi: 10.7812/TPP/21.006.
Takotsubo cardiomyopathy (TTC) is a condition with a good long-term prognosis. However, when the TTC is due to a life-threatening arrhythmia, such as atrioventricular block (AVB), several considerations must be made regarding treatment.
A 71-year-old woman with a history of ischemic stroke presented after a syncopal episode. Before passing out, the patient was walking, nauseous, lightheaded, dizzy, and short of breath. In the emergency department, the blood pressure was 230/120 mmHg, and the heart rate was 38 beats per minute, but the patient was asymptomatic. An electrocardiogram showed a new-onset 2:1 AVB, bifascicular block, and prolonged PR and corrected QT intervals. An echocardiogram revealed a new-onset ejection fraction of 30% to 35%; hypokinesis of the apex, mid-inferoseptum, mid-anterolateral, apical to mid-inferior, and apical to mid-anterior walls; and hyperkinesis of the basal segments. The cardiac catheterization illustrated normal coronary arteries without significant stenosis. Therefore, the patient was diagnosed with TTC and 2:1 AVB. She was treated with lisinopril and metoprolol succinate and received a dual-chamber pacemaker. At the follow-up visit, the patient's ejection fraction and hypokinetic segments improved. She denied any recurrence of syncope, and her pacemaker was functioning appropriately.
When AVB or other arrhythmias initiate a TTC, the patient can experience sudden cardiac death and decompensate quickly. Therefore, clinicians should understand this rare but fatal complication because these patients require pacemakers and beta blockers.
应激性心肌病(Takotsubo 心肌病,TTC)的长期预后良好。然而,当 TTC 由危及生命的心律失常引起时,例如房室传导阻滞(AVB),则需要考虑几种治疗方法。
一名 71 岁女性,有缺血性脑卒中病史,因晕厥发作就诊。晕厥前,患者行走时出现恶心、头晕、头晕和呼吸急促。在急诊科,血压为 230/120mmHg,心率为 38 次/分,但患者无症状。心电图显示新发 2:1AVB、双束支阻滞以及 PR 和校正 QT 间期延长。超声心动图显示新发左心室射血分数为 30%至 35%;心尖、中隔、中前外侧、下壁中到心尖和前壁中到心尖段运动减弱;基底段运动增强。冠状动脉造影显示正常冠状动脉,无明显狭窄。因此,患者被诊断为 TTC 和 2:1AVB。给予依那普利和琥珀酸美托洛尔治疗,并植入双腔起搏器。随访时,患者的射血分数和运动减弱节段改善。她否认再次晕厥,起搏器功能正常。
当 AVB 或其他心律失常引发 TTC 时,患者可能会发生心源性猝死和快速失代偿。因此,临床医生应该了解这种罕见但致命的并发症,因为这些患者需要起搏器和β受体阻滞剂。