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[已撤回]范可尼贫血通路通过诱导乳腺癌细胞中JNK-p53依赖性线粒体凋亡,使细胞对DNA烷化剂敏感。

[Retracted] The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK‑p53‑dependent mitochondrial apoptosis in breast cancer cells.

作者信息

Zhao Lin, Li Yanlin, He Miao, Song Zhiguo, Lin Shu, Yu Zhaojin, Bai Xuefeng, Wang Enhua, Wei Minjie

机构信息

Department of Pharmacology, School of Pharmaceutical Science, China Medical University, Heping Ward, Shenyang, Liaoning 110001, P.R. China.

Institute of Pathology and Pathophysiology, China Medical University, Heping Ward, Shenyang, Liaoning 110001, P.R. China.

出版信息

Int J Oncol. 2022 May;60(5). doi: 10.3892/ijo.2022.5343. Epub 2022 Mar 29.

DOI:10.3892/ijo.2022.5343
PMID:35348188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8997342/
Abstract

Following the publication of the above paper, a concerned reader drew to the Editor's attention that one of the fluorescence microscopic images featured in Fig. 4A had previously appeared in a different form (a portion of data in a different orientation) in another article published by the same authors [Yu J, Zhao L, Li Y, Li N, He M, Bai H, Yu Z, Zheng Z, Mi X, Wang E and We M: Silencing of Fanconi anemia complementation group F exhibits potent chemosensitization of mitomycin C activity in breast cancer cells. J Breast Cancer 16: 291‑299, 2013]. Furthermore, the data panel shown for the 'MDA‑MB‑231/untreated' experiment in Fig. 4A in the above paper appeared to be duplicated as the 'MDA‑MB‑231/MMC + control shRNA' experiment, albeit stained differently. After having received a request from the authors to publish a corrigendum in view of the errors identified in Fig. 4 of the above paper, the Editor of has conducted an independent investigation of the matter and determined that this article should be retracted from the Journal on account of a lack of confidence in the presented data. Upon receiving this decision, the authors were not in agreement that the paper should be retracted. The Editor regrets any inconvenience that has been caused to the readership of the Journal. [the original article was published in International Journal of Oncology 45: 129‑138, 2014; DOI: 10.3892/ijo.2014.2400].

摘要

上述论文发表后,一位关注此事的读者提醒编辑注意,图4A中的一张荧光显微镜图像曾以不同形式(部分数据方向不同)出现在同一作者发表的另一篇文章中[Yu J, Zhao L, Li Y, Li N, He M, Bai H, Yu Z, Zheng Z, Mi X, Wang E and We M: Silencing of Fanconi anemia complementation group F exhibits potent chemosensitization of mitomycin C activity in breast cancer cells. J Breast Cancer 16: 291-299, 2013]。此外,上述论文图4A中所示的“MDA-MB-231/未处理”实验的数据面板似乎与“MDA-MB-231/丝裂霉素C +对照短发夹RNA”实验重复,尽管染色不同。鉴于上述论文图4中发现的错误,在收到作者要求发表勘误的请求后,《国际肿瘤学杂志》编辑对此事进行了独立调查,并确定由于对所呈现数据缺乏信心,应从该期刊撤回本文。收到这一决定后作者不同意撤回该论文。编辑对给本刊读者带来的任何不便表示歉意。[原文发表于《国际肿瘤学杂志》45: 129-138, 2014; DOI: 10.3892/ijo.2014.2400]

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