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[撤回]大豆黄酮通过诱导细胞凋亡和细胞周期阻滞,抑制 Raf/MEK/ERK 级联反应,对 SKOV3 人卵巢癌细胞发挥抗癌活性。

[Retracted] Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade.

机构信息

Department of Gynecology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.

Department of Orthopaedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.

出版信息

Int J Mol Med. 2021 Jun;47(6). doi: 10.3892/ijmm.2021.4929. Epub 2021 Apr 13.

DOI:10.3892/ijmm.2021.4929
PMID:33846770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8041477/
Abstract

Following the publication of the above paper, a concerned reader drew to the Editor's attention that several figures contained data that bore striking similarities to data published in other papers; notably, the western blot data shown in Fig. 6 appeared to have been presented in other studies, notably in Fig. 7B of another paper published around the same time and written by different authors based at different research institutions [Li P, Zhang Z, Zhang F, Zhou H and Sun W: Effects of 3‑tetrazolyl methyl‑3‑hydroxy‑oxindole hybrid (THOH) on cell proliferation, apoptosis, and G2/M cell cycle arrest occurs by targeting platelet‑derived growth factor D (PDGF‑D) and the MEK/ERK signaling pathway in human lung cell lines SK‑LU‑1, A549, and A‑427. Med Sci Monit 24: 4547‑4554, 2018]. Furthermore, cellular images featured in Fig. 2A and B of the above paper appeared in Fig. 2 of the following paper, albeit the data were presented in a different field of view: Yu L, Zhou G‑Q and Li D‑C: MiR‑136 triggers apoptosis in human gastric cancer cells by targeting AEG‑1 and BCL2. Eur Rev Med Pharmacol Sci 22: 7251‑7256, 2018. After having conducted an independent investigation in the Editorial Office, the Editor of has determined that this article should be retracted from the Journal on account of a lack of confidence concerning the originality and the authenticity of the data. The authors were asked for an explanation to account for these concerns, but the Editorial Office never received any reply. The Editor regrets any inconvenience that has been caused to the readership of the Journal. [the original article was published on 41, 3485-3492, 2018; DOI: 10.3892/ijmm.2018.3531].

摘要

在上述论文发表后,一位关注的读者提请编辑注意,其中几个图包含的数据与其他论文发表的数据惊人地相似;特别是,图 6 中所示的 Western blot 数据似乎已在其他研究中呈现,特别是在另一篇由不同作者在不同研究机构撰写的论文的图 7B 中[Li P, Zhang Z, Zhang F, Zhou H 和 Sun W: 3-三唑基甲基-3-羟基-氧吲哚杂合体 (THOH) 通过靶向血小板衍生生长因子 D (PDGF-D) 和 MEK/ERK 信号通路对人肺细胞系 SK-LU-1、A549 和 A-427 中的细胞增殖、凋亡和 G2/M 细胞周期阻滞的影响。医学科学监测 24: 4547-4554, 2018]。此外,上述论文中的图 2A 和 B 的细胞图像出现在以下论文的图 2 中,尽管数据是以不同的视场呈现的:Yu L, Zhou G-Q 和 Li D-C: MiR-136 通过靶向 AEG-1 和 BCL2 触发人胃癌细胞凋亡。欧洲评论医学和药理学科学 22: 7251-7256, 2018。在编辑部进行了独立调查后, 杂志的编辑决定将这篇文章从杂志上撤回,原因是对数据的原创性和真实性缺乏信心。编辑要求作者对此作出解释,但从未收到回复。编辑对给杂志的读者带来的任何不便表示歉意。[原始文章发表于 2018 年 8 月 41 日,第 3485-3492 页;DOI: 10.3892/ijmm.2018.3531]。

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