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一名9岁髋关节溶解症女性患者使用阿达木单抗治疗后关节炎缓解,软骨部分恢复。

Arthritis remission with partial cartilage restoration in a 9-year-old female with hip chondrolysis following treatment with adalimumab.

作者信息

Fotis Lampros, Kanellopoulos Anastasios, Papakonstantinou Olympia

机构信息

Department of Pediatrics, National and Kapodistrian University of Athens, "ATTIKON" General Hospital, Athens, Greece.

Department of Orthopedics, IASO Children's Hospital, Athens, Greece.

出版信息

Mod Rheumatol Case Rep. 2023 Jan 3;7(1):227-231. doi: 10.1093/mrcr/rxac024.

DOI:10.1093/mrcr/rxac024
PMID:35348735
Abstract

Hip chondrolysis is observed primarily or secondary to other diseases and is a rare but yet debilitating disease, characterised by loss of cartilage of the femoral epiphysis and significant restriction of motion. We present the case of a 9-year-old female diagnosed with hip chondrolysis associated with probable juvenile psoriatic arthritis. Avoidance of weight-bearing activities and treatment with corticosteroids, methotrexate, and adalimumab followed by aquatic therapy resulted in clinical and radiographic improvement as well as partial cartilage regeneration.

摘要

髋关节溶解主要是原发性的,或继发于其他疾病,是一种罕见但使人衰弱的疾病,其特征是股骨骨骺软骨丧失和运动严重受限。我们报告一例9岁女性被诊断为与可能的青少年银屑病关节炎相关的髋关节溶解病例。避免负重活动,并使用皮质类固醇、甲氨蝶呤和阿达木单抗治疗,随后进行水疗,结果临床和影像学均有改善,软骨也部分再生。

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