Sichuan Provincial Laboratory of Orthopaedic Engineering, Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
State Key Laboratory of Trauma, Burn and Combined Injury, Department of Emergency, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Biomed Microdevices. 2024 Jan 23;26(1):12. doi: 10.1007/s10544-023-00686-8.
The rise in drug resistance in pathogenic bacteria greatly endangers public health in the post-antibiotic era, and drug-resistant bacteria currently pose a great challenge not only to the community but also to clinical procedures, including surgery, stent implantation, organ transplantation, and other medical procedures involving any open wound and compromised human immunity. Biofilm-associated drug failure, as well as rapid resistance to last-resort antibiotics, necessitates the search for novel treatments against bacterial infection. In recent years, the flourishing development of nanotechnology has provided new insights for exploiting promising alternative therapeutics for drug-resistant bacteria. Metallic agents have been applied in antibacterial usage for several centuries, and the functional modification of metal-based biomaterials using nanotechnology has now attracted great interest in the antibacterial field, not only for their intrinsic antibacterial nature but also for their ready on-demand functionalization and enhanced interaction with bacteria, rendering them with good potential in further translation. However, the possible toxicity of MNPs to the host cells and tissue still hinders its application, and current knowledge on their interaction with cellular pathways is not enough. This review will focus on recent advances in developing metallic nanoparticles (MNPs), including silver, gold, copper, and other metallic nanoparticles, for antibacterial applications, and their potential mechanisms of interaction with pathogenic bacteria as well as hosts.
耐药菌的出现极大地威胁着后抗生素时代的公共卫生，耐药菌目前不仅对社区，而且对临床操作，包括手术、支架植入、器官移植和其他涉及任何开放性伤口和人类免疫受损的医疗程序，都构成了巨大挑战。生物膜相关的药物失败以及对最后手段抗生素的快速耐药性，需要寻找针对细菌感染的新型治疗方法。近年来，纳米技术的蓬勃发展为开发针对耐药菌的有前途的替代疗法提供了新的思路。金属制剂在抗菌应用中已经使用了几个世纪，现在纳米技术对基于金属的生物材料的功能修饰在抗菌领域引起了极大的兴趣，不仅因为它们具有内在的抗菌特性，还因为它们可以按需进行功能化，并增强与细菌的相互作用，因此具有很好的进一步转化潜力。然而，MNPs 对宿主细胞和组织的潜在毒性仍然阻碍了其应用，并且目前对它们与细胞途径相互作用的了解还不够。本文综述了近年来开发用于抗菌应用的金属纳米粒子（MNPs），包括银、金、铜和其他金属纳米粒子的进展，以及它们与病原菌和宿主相互作用的潜在机制。
