State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
Neurochem Res. 2022 Dec;47(12):3627-3634. doi: 10.1007/s11064-022-03586-0. Epub 2022 Mar 28.
Parkinson's disease (PD) is a chronic neurodegenerative disease mainly characterized by movement disorders and other non-motor symptoms, including the loss of dopaminergic neurons in the substantia nigra parts. Abnormal α-synuclein aggregation in the brain is closely associated with the loss of dopaminergic neurons. α-synuclein can propagate in the central nervous system (CNS) and periphery under pathological conditions. Many researches have focused on its aggregation and distribution in the CNS and explored its relationship with PD. But in recent years, the distribution of α-synuclein in peripheral tissues have been paid much attention. This review summarized the distribution of α-synuclein in the choroid plexus, blood, saliva, gastrointestine and other tissues, and discussed the potential mechanism of α-synuclein aggregation, providing a basis for the early diagnosis and intervention of PD.
帕金森病（PD）是一种慢性神经退行性疾病，主要表现为运动障碍和其他非运动症状，包括黑质部位多巴胺能神经元的丧失。脑内异常的α-突触核蛋白聚集与多巴胺能神经元的丧失密切相关。在病理条件下，α-突触核蛋白可以在中枢神经系统（CNS）和外周组织中传播。许多研究集中在其在中枢神经系统中的聚集和分布，并探讨了其与 PD 的关系。但近年来，α-突触核蛋白在周围组织中的分布受到了广泛关注。本综述总结了α-突触核蛋白在脉络丛、血液、唾液、胃肠道等组织中的分布，并讨论了α-突触核蛋白聚集的潜在机制，为 PD 的早期诊断和干预提供了依据。
