通过 -杂环卡宾有机催化实现 1,3-烯炔的自由基酰基烷基化反应，以获得烯丙基酮。
Radical Acylalkylation of 1,3-Enynes To Access Allenic Ketones via -Heterocyclic Carbene Organocatalysis.
机构信息
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P. R. China.
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, P. R. China.
出版信息
J Org Chem. 2022 Apr 15;87(8):5229-5241. doi: 10.1021/acs.joc.2c00037. Epub 2022 Mar 29.
An -heterocyclic carbene organocatalytic 1,4-difunctionalization of 1,3-enynes was developed. This organocatalytic strategy was suitable for a broad spectrum of substrates to efficiently synthesize allenic ketones bearing diverse substituents. Preliminary mechanistic studies suggest a radical reaction pathway for this organocatalytic acylalkylation process.
开发了一种 -杂环卡宾有机催化的 1,3-烯炔的 1,4-双官能化反应。这种有机催化策略适用于广泛的底物，能够高效合成带有各种取代基的烯基酮。初步的机理研究表明，这种有机催化的酰基烷基化过程可能遵循自由基反应途径。
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