Li Yajun, Bao Hongli
Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences Fuzhou 350002 P. R. of China
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences P. R. of China.
Chem Sci. 2022 Jun 29;13(29):8491-8506. doi: 10.1039/d2sc02573f. eCollection 2022 Jul 29.
Allenes are valuable organic molecules that feature unique physical and chemical properties. They are not only often found in natural products, but also act as versatile building blocks for the access of complex molecular targets, such as natural products, pharmaceuticals, and functional materials. Therefore, many remarkable and elegant methodologies have been established for the synthesis of allenes. Recently, more and more methods for radical synthesis of allenes have been developed, clearly emphasizing the associated great synthetic values. In this perspective, we will discuss recent important advances in the synthesis of allenes radical intermediates by categorizing them into different types of substrates as well as distinct catalytic systems. The mechanistic studies and synthetic challenges will be highlighted.
联烯是具有独特物理和化学性质的重要有机分子。它们不仅经常存在于天然产物中，而且还作为合成复杂分子目标（如天然产物、药物和功能材料）的通用构建块。因此，已经建立了许多卓越且精巧的联烯合成方法。最近，越来越多的联烯自由基合成方法被开发出来，这清楚地凸显了其巨大的合成价值。从这个角度出发，我们将通过将联烯自由基中间体的合成方法按照不同类型的底物以及不同的催化体系进行分类，来讨论近期的重要进展。同时将突出机理研究和合成挑战。
