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在 Medicare 受益人群中,与血管内主动脉瘤修复转为开放修复相关的当代发生率、结局和生存情况。

Contemporary incidence, outcomes, and survival associated with endovascular aortic aneurysm repair conversion to open repair among Medicare beneficiaries.

机构信息

Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH.

Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, FL.

出版信息

J Vasc Surg. 2022 Sep;76(3):671-679.e2. doi: 10.1016/j.jvs.2022.02.036. Epub 2022 Mar 26.

Abstract

OBJECTIVE

The widespread application of endovascular abdominal aortic aneurysm repair (EVAR) has ushered in an era of requisite postoperative surveillance and the potential need for reintervention. The national prevalence and results of EVAR conversion to open repair, however, remain poorly defined. The purpose of this analysis was to define the incidence of open conversion and its associated outcomes.

METHODS

The SVS Vascular Quality Initiative EVAR registry linked to Medicare claims via Vascular Implants Surveillance and Interventional Outcomes Network was queried for open conversions after initial EVAR procedures from 2003 to 2016. Cumulative conversion incidence within up to 5 years after EVAR and outcomes after open intervention were determined. Multivariable logistic regressions were used to identify independent predictors of conversion and mortality.

RESULTS

Among 15,937 EVAR patients, 309 (1.9%) underwent an open conversion: 43% (n = 132) early (<30 days) and 57% (n = 177) late (>30 days). The longitudinally observed rate of conversion was constant over time, as well as by geographic region. Independent predictors of conversion included female sex (hazard ratio [HR], 1.49; P < .001), aneurysm diameter or more than 6.0 cm at the time of index EVAR (HR, 1.74; P < .001), nonelective repair (compared with elective presentation: HR, 1.72; P < .001), and aortouni-iliac repairs (HR, 2.19; P < .001). In contrast, adjunctive operative procedures such as endo-anchors or cuff extensions (HR, 0.62; P = .06) were protective against long-term conversion. Both early (HR, 1.6; P < .001) and late (HR, 1.26; P = .07) open conversions were associated with significant 30-day (total cohort, 15%) and 1-year mortality (total cohort, 25%). Patients undergoing open conversion experienced high rates of 30-day readmission (42%) and cardiac (45%), renal (32%), and pulmonary (30%) complications.

CONCLUSIONS

This large, registry-based analysis is among the first to document the incidence and outcomes for open conversion after EVAR in a national cohort with long-term follow-up. Importantly, women, patients with large aneurysms, and complex anatomy, as well as urgent or emergent EVARs are at an increased risk for open conversion. It seems that more conversions are performed in the early postoperative period, despite perceptions that conversion is a delayed phenomenon. In all instances, conversion is associated with significant morbidity and mortality and highlights the importance of appropriate patient selection at the time of index EVAR.

摘要

目的

血管内腹主动脉瘤修复术(EVAR)的广泛应用开创了术后必需监测和潜在再介入的时代。然而,全国范围内 EVAR 转为开放修复的流行程度和结果仍未明确定义。本分析的目的是确定开放转换的发生率及其相关结果。

方法

通过血管植入物监测和干预结果网络,从 2003 年至 2016 年,对最初的 EVAR 手术后的开放转换,对 SVS 血管质量倡议 EVAR 登记处进行了查询。确定 EVAR 后长达 5 年内的累积转换发生率和开放干预后的结果。使用多变量逻辑回归来确定转换和死亡率的独立预测因素。

结果

在 15937 例 EVAR 患者中,有 309 例(1.9%)进行了开放转换:43%(n=132)为早期(<30 天),57%(n=177)为晚期(>30 天)。随着时间的推移,转换的纵向观察发生率保持不变,而且在地理区域之间也是如此。转换的独立预测因素包括女性(风险比[HR],1.49;P<.001)、指数 EVAR 时的动脉瘤直径或超过 6.0cm(HR,1.74;P<.001)、非选择性修复(与选择性表现相比:HR,1.72;P<.001)和腹主动脉-髂动脉修复(HR,2.19;P<.001)。相比之下,辅助手术程序,如内锚或袖带扩展(HR,0.62;P=0.06)可降低长期转换的风险。早期(HR,1.6;P<.001)和晚期(HR,1.26;P=0.07)的开放转换均与 30 天(总队列,15%)和 1 年死亡率(总队列,25%)显著相关。接受开放转换的患者 30 天内再入院率(42%)、心脏(45%)、肾脏(32%)和肺部(30%)并发症发生率高。

结论

这项基于大型注册的分析是首次在全国队列中对 EVAR 后开放转换的发生率和结果进行的研究,且具有长期随访。重要的是,女性、大动脉瘤患者和复杂解剖结构,以及紧急或紧急 EVAR 患者发生开放转换的风险增加。尽管人们认为转换是一种延迟现象,但似乎在术后早期进行了更多的转换。在所有情况下,转换都与显著的发病率和死亡率相关,并强调了在进行 EVAR 时进行适当的患者选择的重要性。

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