Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Department of Reconstructive Orthopaedics, Karolinska University Hospital, Stockholm, Sweden.
Sci Rep. 2022 Mar 29;12(1):5339. doi: 10.1038/s41598-022-09389-1.
Studies on outcomes after four-level anterior cervical discectomy and fusion (ACDF) are limited in the literature. The purpose of this study was to report on clinical outcomes and revision rates following four-level ACDF. Patients operated with four-level ACDF were identified in a prospectively accrued single institution database. Outcome scores included the Neck Disability Index (NDI) and Visual Analogue Scale (VAS) for neck and arm pain. Reoperation rates were determined. Any complications were identified from a review of the medical records. Twenty-eight patients with a minimum of 12 months follow up were included in the analysis. The mean age at surgery was 58.5 years. The median radiographic follow up time was 23 (IQR = 16-31.25) months. Cervical lordosis was significantly improved postoperatively (- 1 to - 13, p < 0.001). At the median 24 (IQR = 17.75-39.50) months clinical follow up time, there was a significant improvement in the NDI (38 to 28, p = 0.046) and VAS for neck pain scores (5.1 to 3, p = 0.012). The most common perioperative complication was transient dysphagia (32%) followed by hoarseness (14%). Four (14%) patients required revision surgery at a median 11.5 (IQR = 2-51) months postoperatively. The results of this study indicate that patients who undergo four-level ACDF have a significant improvement in clinical outcomes at median 24 months follow up. Stand-alone four-level ACDF is a valid option for the management of complex cervical degenerative conditions.
四节段颈椎前路椎体间融合术(ACDF)的研究结果在文献中有限。本研究旨在报告四节段 ACDF 后的临床结果和翻修率。在一个前瞻性累积的单机构数据库中确定了接受四节段 ACDF 手术的患者。结果评分包括颈部残疾指数(NDI)和颈部和手臂疼痛的视觉模拟量表(VAS)。确定了再手术率。从病历回顾中确定了任何并发症。分析中包括了 28 例至少有 12 个月随访的患者。手术时的平均年龄为 58.5 岁。中位数放射学随访时间为 23(IQR=16-31.25)个月。颈椎前凸术后显著改善(-1 至-13,p<0.001)。在中位数为 24(IQR=17.75-39.50)个月的临床随访时间,NDI(从 38 分降至 28 分,p=0.046)和颈部疼痛 VAS 评分(从 5.1 分降至 3 分,p=0.012)均有显著改善。最常见的围手术期并发症是短暂性吞咽困难(32%),其次是声音嘶哑(14%)。四例(14%)患者在术后中位数 11.5(IQR=2-51)个月需要进行翻修手术。本研究结果表明,接受四节段 ACDF 的患者在中位数 24 个月的随访中临床结果显著改善。单纯性四节段 ACDF 是治疗复杂颈椎退行性疾病的有效选择。