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尿道下裂:经验教训。发病率、流行病学、手术、研究、并发症和结局概述。

Hypospadias: lessons learned. An overview of incidence, epidemiology, surgery, research, complications, and outcomes.

机构信息

University of Colorado, Aurora, CO, USA.

Center for Childrens' Surgery Children's Hospital Colorado, Aurora, CO, USA.

出版信息

Int J Impot Res. 2023 Feb;35(1):61-66. doi: 10.1038/s41443-022-00563-7. Epub 2022 Mar 29.

DOI:10.1038/s41443-022-00563-7
PMID:35352016
Abstract

Hypospadias is a common condition and familiar, though sometimes challenging territory for the pediatric urologist. This review is a summary of hypospadias incidence, epidemiology, surgery, research, and complications intended for the non-specialist. It outlines the history, the principles of surgery for hypospadias, and the long-term outcomes.

摘要

尿道下裂是一种常见的疾病,虽然对小儿泌尿科医生来说有时具有挑战性,但也并不陌生。本文回顾了尿道下裂的发病率、流行病学、手术、研究和并发症,旨在为非专业人士提供概述。本文概述了尿道下裂的历史、手术原则和长期结果。

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1
Hypospadias: lessons learned. An overview of incidence, epidemiology, surgery, research, complications, and outcomes.尿道下裂:经验教训。发病率、流行病学、手术、研究、并发症和结局概述。
Int J Impot Res. 2023 Feb;35(1):61-66. doi: 10.1038/s41443-022-00563-7. Epub 2022 Mar 29.
2
[Classification of urethroplasty complications in hypospadias].[尿道下裂尿道成形术并发症的分类]
Urologiia. 2010 Jan-Feb(1):17-21.
3
[Hypospadias surgery--etiology of complications].[尿道下裂手术——并发症的病因]
Chirurgia (Bucur). 2007 Nov-Dec;102(6):687-92.
4
Better Defining the Spectrum of Adult Hypospadias: Examining the Effect of Childhood Surgery on Adult Presentation.更精准地界定成人尿道下裂的范围:探究儿童期手术对成人表现的影响。
Urology. 2017 Jan;99:281-286. doi: 10.1016/j.urology.2016.07.057. Epub 2016 Sep 28.
5
Prevalence, repairs and complications of hypospadias: an Australian population-based study.尿道下裂的患病率、修复情况及并发症:一项基于澳大利亚人群的研究。
Arch Dis Child. 2015 Nov;100(11):1038-43. doi: 10.1136/archdischild-2015-308809. Epub 2015 Aug 26.
6
Adolescent and Young Adult Urogenital Outcome following Childhood Hypospadias Repair: Perfection Revisited.儿童尿道下裂修复术后青少年和年轻成人泌尿生殖结局:完美的再审视。
J Urol. 2021 Sep;206(3):734-744. doi: 10.1097/JU.0000000000001869. Epub 2021 May 6.
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Oral mucosa graft for repair of hypospadias: outcomes at puberty.口腔黏膜移植修复尿道下裂:青春期结局。
J Urol. 2010 Dec;184(6):2504-8. doi: 10.1016/j.juro.2010.08.042. Epub 2010 Oct 18.
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The modified Ulaanbaatar procedure: Reduced complications and enhanced cosmetic outcome for the most severe cases of hypospadias.改良的乌兰巴托手术:减少重度尿道下裂病例的并发症并改善美观效果。
J Pediatr Urol. 2017 Aug;13(4):353.e1-353.e7. doi: 10.1016/j.jpurol.2017.04.012. Epub 2017 May 18.
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Testosterone prior to hypospadias repair: Postoperative complication rates and long-term cosmetic results, penile length and body height.尿道下裂修复术前的睾酮:术后并发症发生率、长期外观效果、阴茎长度和身高
J Pediatr Urol. 2018 Feb;14(1):31.e1-31.e8. doi: 10.1016/j.jpurol.2017.09.020. Epub 2017 Oct 27.
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Surgical Approaches and Long-Term Outcomes in Adults with Complex Reoperative Hypospadias Repair.成人复杂复发性尿道下裂修复的手术入路和长期疗效。
J Urol. 2018 May;199(5):1296-1301. doi: 10.1016/j.juro.2017.11.078. Epub 2017 Dec 1.

引用本文的文献

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Surgical approaches for distal urethral strictures after failed hypospadias repair: a systematic review and meta-analysis.尿道下裂修复失败后远端尿道狭窄的手术方法:系统评价与Meta分析
Int J Impot Res. 2025 Sep 15. doi: 10.1038/s41443-025-01167-7.
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A case report of hypospadias combined with polyorchidism.一例尿道下裂合并多睾症的病例报告。
Urol Case Rep. 2024 Dec 24;58:102924. doi: 10.1016/j.eucr.2024.102924. eCollection 2025 Jan.
3
Urethral Mobilisation and Glanuloplasty Technique for Primary and Second-Stage Repair of Hypospadias: A Single Hospital Experience.

本文引用的文献

1
Adolescent and Young Adult Urogenital Outcome following Childhood Hypospadias Repair: Perfection Revisited.儿童尿道下裂修复术后青少年和年轻成人泌尿生殖结局:完美的再审视。
J Urol. 2021 Sep;206(3):734-744. doi: 10.1097/JU.0000000000001869. Epub 2021 May 6.
2
How Far Should We Explore Hypospadias? Next-generation Sequencing Applied to a Large Cohort of Hypospadiac Patients.我们应该在尿道下裂研究上走多远?下一代测序应用于大型尿道下裂患者队列。
Eur Urol. 2021 Apr;79(4):507-515. doi: 10.1016/j.eururo.2020.12.036. Epub 2021 Jan 16.
3
Parental decision regret in childhood hypospadias surgery: A systematic review.
尿道下裂一期和二期修复的尿道游离及龟头成形术:单中心经验
Cureus. 2024 Jun 26;16(6):e63189. doi: 10.7759/cureus.63189. eCollection 2024 Jun.
4
Preoperative parent education and postoperative nurse-led care for boys versus routine hospital care for urethroplasty for hypospadias in Western China: a retrospective study.中国西部尿道下裂成形术:术前家长教育和术后护士主导护理对男孩与常规医院护理的回顾性研究。
Turk J Med Sci. 2024 Jan 3;54(2):459-470. doi: 10.55730/1300-0144.5811. eCollection 2024.
5
A mobile application for postoperative education of caregivers of children with congenital hypospadias: Requirement analysis.一款用于先天性尿道下裂患儿照顾者术后教育的移动应用程序:需求分析
Health Sci Rep. 2024 Mar 11;7(3):e1942. doi: 10.1002/hsr2.1942. eCollection 2024 Mar.
小儿尿道下裂手术中父母的决策遗憾:一项系统评价。
J Paediatr Child Health. 2020 Oct;56(10):1514-1520. doi: 10.1111/jpc.15075. Epub 2020 Sep 3.
4
Comparing the outcomes of tubularized incised plate urethroplasty and dorsal inlay graft urethroplasty in children with hypospadias: a systematic review and meta-analysis.比较管状切开板尿道成形术和背侧镶嵌移植尿道成形术治疗小儿尿道下裂的疗效:一项系统评价和荟萃分析。
J Pediatr Urol. 2020 Apr;16(2):154-161. doi: 10.1016/j.jpurol.2020.01.009. Epub 2020 Jan 22.
5
Hot spots in fetal human penile and clitoral development.胎儿人类阴茎和阴蒂发育的热点。
Differentiation. 2020 Mar-Apr;112:27-38. doi: 10.1016/j.diff.2019.11.001. Epub 2019 Dec 4.
6
Lifelong Congenital Urology: The Challenges for Patients and Surgeons.终身先天性泌尿学:患者和外科医生面临的挑战。
Eur Urol. 2019 Jun;75(6):1001-1007. doi: 10.1016/j.eururo.2019.03.019. Epub 2019 Mar 29.
7
The use of postoperative prophylactic antibiotics in stented distal hypospadias repair: a systematic review and meta-analysis.支架型远端尿道下裂修复术后预防性使用抗生素的效果:系统评价和荟萃分析。
J Pediatr Urol. 2019 Apr;15(2):138-148. doi: 10.1016/j.jpurol.2018.10.012. Epub 2018 Nov 1.
8
Development of the human penis and clitoris.人类阴茎和阴蒂的发育。
Differentiation. 2018 Sep-Oct;103:74-85. doi: 10.1016/j.diff.2018.08.001. Epub 2018 Aug 23.
9
Patients with disorders of sex development and proximal hypospadias are at high risk for reoperation.患有性发育障碍和近端尿道下裂的患者有再次手术的高风险。
World J Urol. 2018 Dec;36(12):2051-2058. doi: 10.1007/s00345-018-2350-3. Epub 2018 May 31.
10
Regulation of masculinization: androgen signalling for external genitalia development.男性化的调节:雄激素信号对外部生殖器发育的作用。
Nat Rev Urol. 2018 Jun;15(6):358-368. doi: 10.1038/s41585-018-0008-y.