N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2022 Mar;172(5):653-657. doi: 10.1007/s10517-022-05449-8. Epub 2022 Mar 30.
Bacteria forming the resident microbiome of the tumor are an integral component of its microenvironment. The interaction of the tumor microbiome with the tumor or tumor stromal cells is not well understood. We hypothesized that bacteria in the tumor microenvironment induce macrophage tolerance. Macrophage tolerance is a phenomenon of macrophage inability to respond to a repetitive inflammatory stimulus, which leads to a loss of cytotoxic activity. We studied the development of macrophage tolerance under the influence of bacteria and cytokines of the tumor microenvironment in vitro. It was found that the macrophage tolerance in the tumor stroma can develop in response to bacterial cell wall components and inflammatory factors. The acquired tolerance is inability of macrophages to produce proinflammatory cytokines TNFα, IL-1β, and MCP-1 and activation of the production of immunosuppressive IL-10.
肿瘤常驻微生物组中的细菌是其微环境的一个组成部分。肿瘤微生物组与肿瘤或肿瘤基质细胞的相互作用还没有被很好地理解。我们假设肿瘤微环境中的细菌会诱导巨噬细胞耐受。巨噬细胞耐受是巨噬细胞无法对重复的炎症刺激作出反应的现象，这导致细胞毒性活性丧失。我们在体外研究了在细菌和肿瘤微环境细胞因子的影响下巨噬细胞耐受的发展。结果发现，肿瘤基质中的巨噬细胞耐受可以对细菌细胞壁成分和炎症因子作出反应而发展。获得性耐受是指巨噬细胞无法产生促炎细胞因子 TNFα、IL-1β 和 MCP-1，并且抑制性细胞因子 IL-10 的产生被激活。
