MCN Am J Matern Child Nurs. 2022;47(4):195-206. doi: 10.1097/NMC.0000000000000832.
The significant crying of infantile colic adds stress to the infant and their family, yet it has no recognized etiology. Gastrointestinal health problems and dysfunction have been suspected in the etiology of colic. Disruptions to the microbiome colonization of the gastrointestinal system may lead to excess gas and inflammation that are associated with the crying of colic. Infants with colic have increased colonization with gas-producing bacteria, like Escherichia coli and Klebsiella , and they have lower colonization of anti-inflammatory bacteria, like Bifidobacterium and Lactobacillus . Colic is known to self-resolve around 3 months of age. However, few researchers have investigated how the microbiome may be changing at colic's natural resolution without the intervention of a probiotic. With a better understanding of what leads to colic's self-resolution, future researchers may be able to identify more effective therapies for colic prevention or treatment. This scoping review presents the collective evidence from 21 original, primary research articles on what is known about the gastrointestinal microbiome at colic onset and resolution.
婴儿腹绞痛的剧烈哭闹会给婴儿及其家庭带来压力，但它没有明确的病因。胃肠道健康问题和功能障碍被怀疑与绞痛的病因有关。胃肠道系统微生物组定植的紊乱可能导致与腹绞痛相关的过多气体和炎症。患有腹绞痛的婴儿会过度定植产气体的细菌，如大肠杆菌和克雷伯氏菌，而定植抗炎细菌，如双歧杆菌和乳酸杆菌的数量会减少。腹绞痛通常会在 3 个月左右自行缓解。然而，很少有研究人员调查在没有益生菌干预的情况下，微生物组在腹绞痛自然缓解时是如何变化的。通过更好地了解导致腹绞痛自行缓解的原因，未来的研究人员或许能够为腹绞痛的预防或治疗找到更有效的疗法。本范围综述介绍了 21 篇原始主要研究文章的综合证据，这些文章涉及腹绞痛发作和缓解时的胃肠道微生物组。
