Department of Veterinary Surgery and Radiology, West Bengal University of Animal & Fishery Sciences, Kolkata, 700037, India.
Department of Veterinary Physiology, West Bengal University of Animal & Fishery Sciences, Kolkata, 700037, India.
Chem Rec. 2022 Jun;22(6):e202200008. doi: 10.1002/tcr.202200008. Epub 2022 Mar 30.
Despite the recent advances in reconstructive orthopedics; fracture union is a challenge to bone regeneration. Concurrent angiogenesis is a complex process governed by events, delicately entwined with osteogenesis. However, poorly perfused scaffolds have lower success rates; necessitating the need for a better vascular component, which is important for the delivery of nutrients, oxygen, waste elimination, recruitment of cells for optimal bone repair. This review highlights the latest strategies to promote biomaterial-based scaffold vascularization by incorporation of cells, growth factors, inorganic ions, etc. into natural or synthetic polymers, ceramic materials, or composites of organic and inorganic compounds. Furthermore, it emphasizes structural modifications, biophysical stimuli, and natural molecules to fabricate scaffolds aiding the genesis of dense vascularization following their implantation to manifest a compatible regenerative microenvironment without graft rejection.
尽管近年来在矫形重建领域取得了进展，但骨折愈合仍然是骨再生面临的挑战。伴随的血管生成是一个复杂的过程，由一系列事件控制，与成骨过程精细交织。然而，灌注不良的支架成功率较低；因此需要更好的血管成分，这对于营养物质、氧气的输送、废物的清除以及细胞的募集以实现最佳的骨修复都很重要。本综述强调了通过将细胞、生长因子、无机离子等掺入天然或合成聚合物、陶瓷材料或有机和无机化合物的复合材料中，来促进基于生物材料的支架血管化的最新策略。此外，本综述还强调了结构修饰、生物物理刺激和天然分子来制造支架，以帮助在植入后形成致密的血管化，表现出一种无排斥反应的、相容的再生微环境。
