Alkhursani Sheikha A, Ghobashy Mohamed Mohamady, Al-Gahtany Samera Ali, Meganid Abeer S, Abd El-Halim Shady M, Ahmad Zubair, Khan Farhat S, Atia Gamal Abdel Nasser, Cavalu Simona
Faculty of Science and Humanities-Jubail, Imam Abdulrahman Bin Faisal University, Jubail 31441, Saudi Arabia.
Radiation Research of Polymer Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo 11787, Egypt.
Polymers (Basel). 2022 Sep 10;14(18):3791. doi: 10.3390/polym14183791.
This review's objectives are to provide an overview of the various kinds of biopolymer hydrogels that are currently used for bone tissue and periodontal tissue regeneration, to list the advantages and disadvantages of using them, to assess how well they might be used for nanoscale fabrication and biofunctionalization, and to describe their production processes and processes for functionalization with active biomolecules. They are applied in conjunction with other materials (such as microparticles (MPs) and nanoparticles (NPs)) and other novel techniques to replicate physiological bone generation more faithfully. Enhancing the biocompatibility of hydrogels created from blends of natural and synthetic biopolymers can result in the creation of the best scaffold match to the extracellular matrix (ECM) for bone and periodontal tissue regeneration. Additionally, adding various nanoparticles can increase the scaffold hydrogel stability and provide a number of biological effects. In this review, the research study of polysaccharide hydrogel as a scaffold will be critical in creating valuable materials for effective bone tissue regeneration, with a future impact predicted in repairing bone defects.
本综述的目的是概述目前用于骨组织和牙周组织再生的各种生物聚合物水凝胶，列出使用它们的优缺点，评估它们在纳米级制造和生物功能化方面的适用性，以及描述它们的生产过程和用活性生物分子进行功能化的过程。它们与其他材料（如微粒（MPs）和纳米颗粒（NPs））以及其他新技术联合应用，以更忠实地复制生理性骨生成。提高由天然和合成生物聚合物共混物制成的水凝胶的生物相容性，可产生与细胞外基质（ECM）最匹配的支架，用于骨和牙周组织再生。此外，添加各种纳米颗粒可提高支架水凝胶的稳定性，并提供多种生物学效应。在本综述中，多糖水凝胶作为支架的研究对于创造有效的骨组织再生有价值的材料至关重要，预计对修复骨缺损有未来影响。
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