Liu Yanting, Tan Sichuang, Wu Yongbin, Tan Sipin
Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
Sepsis Translational Medicine Key Lab of Hunan Province, Changsha, People's Republic of China.
DNA Cell Biol. 2022 Apr;41(4):368-380. doi: 10.1089/dna.2021.1072. Epub 2022 Mar 29.
Ferroptosis is a novel form of cell death characterized by the iron-dependent accumulation of lipid peroxides and is different from other types of cell death. The mechanisms of ferroptosis are discussed in the review, including System Xc-, Glutathione Peroxidase 4 pathway, Ferroptosis Suppressor Protein 1 and Dihydroorotate Dehydrogenase pathway. Ferroptosis is associated with the occurrence of various diseases, including sepsis. Research in recent years has displayed that ferroptosis is involved in sepsis occurrence and development. Iron chelators can inhibit the development of sepsis and improve the survival rate of septic mice. The ferroptotic cells can release damage-associated molecular patterns and lipid peroxidation, which further mediate inflammatory responses. Ferroptosis inhibitors can resist sepsis-induced multiple organ dysfunction and inflammation. Finally, we reviewed ferroptosis, an iron-dependent form of cell death that is different from other types of cell death in biochemistry, morphology, and major regulatory mechanisms, which is involved in multiple organ injuries caused by sepsis. Exploring the relationship between sepsis and ferroptosis may yield new treatment targets for sepsis.
铁死亡是一种新型细胞死亡形式，其特征在于脂质过氧化物的铁依赖性积累，且不同于其他类型的细胞死亡。本综述讨论了铁死亡的机制，包括胱氨酸/谷氨酸反向转运体（System Xc-）、谷胱甘肽过氧化物酶4途径、铁死亡抑制蛋白1和二氢乳清酸脱氢酶途径。铁死亡与包括脓毒症在内的多种疾病的发生相关。近年来的研究表明，铁死亡参与脓毒症的发生和发展。铁螯合剂可抑制脓毒症的发展并提高脓毒症小鼠的存活率。铁死亡细胞可释放损伤相关分子模式和脂质过氧化产物，进而介导炎症反应。铁死亡抑制剂可抵抗脓毒症诱导的多器官功能障碍和炎症。最后，我们综述了铁死亡，这是一种铁依赖性细胞死亡形式，在生物化学、形态学和主要调节机制方面不同于其他类型的细胞死亡，其参与了脓毒症所致的多器官损伤。探索脓毒症与铁死亡之间的关系可能会为脓毒症带来新的治疗靶点。
