Le Ha Thanh-Thai, Huynh Nam Cong-Nhat, Nguyen-Ho Quynh-Anh, Nguyen Thuy Thu, Le Son Hoang, Nguyen Ly Thi-Bich
Department of Oral Surgery, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Dental Basic Sciences, and Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Photobiomodul Photomed Laser Surg. 2022 Apr;40(4):245-251. doi: 10.1089/photob.2021.0110. Epub 2022 Mar 29.
This study aimed to compare the effects of photobiomodulation therapy (PBMT) on analgesic and inflammatory reduction with that of ibuprofen following surgical removal of impacted mandibular third molars (IMTMs). A randomized, split-mouth clinical trial was performed on patients undergoing bilateral IMTM removal. PBMT [gallium aluminum arsenide (GaAlAs) laser] with specific parameters (wavelength of 810 nm, power of 0.5% ± 20% W, and energy density of 4 J/cm) was applied randomly on one side of the mouth immediately after surgery and 1 and 2 days after surgery. The pain level was self-rated with a Likert scale at 2, 4, 6, 24, and 48 h postoperatively. Swelling and trismus were measured on the first and second day after surgery. Saliva was collected for measuring pre- and postoperative salivary immunoglobulin A (sIgA) concentrations with the sandwich ELISA test. The study sample included 25 patients (average age of 22.88 years) with 50 bilateral symmetrical IMTMs. Pain level was highest at 2 h after surgery in both groups and gradually decreased over time ( < 0.01). Swelling and trismus at 48 h were higher than at 24 h ( < 0.01). Within the first 48 h postoperatively, pain level, swelling, and trismus were significantly lower in the PBMT group ( < 0.05). Postoperative sIgA was also significantly lower in the PBMT group ( < 0.05). In short-term and specific conditions of this study, it was found that PBMT helped promote postoperative pain relief and anti-inflammation after surgical removal of IMTMs. The results suggested that there may be a link between a decrease in salivary sIgA levels and decrease in inflammatory processes after PBMT. Trial Registration No. NCT04280809 at ClinicalTrials.gov.
本研究旨在比较光生物调节疗法（PBMT）与布洛芬在拔除下颌阻生第三磨牙（IMTMs）后对镇痛和减轻炎症的效果。对接受双侧IMTMs拔除术的患者进行了一项随机、双盲临床试验。采用特定参数（波长810nm、功率0.5%±20%W、能量密度4J/cm）的PBMT[砷化镓铝（GaAlAs）激光]在术后即刻、术后1天和2天随机照射口腔一侧。术后2、4、6、24和48小时采用李克特量表进行疼痛自评。术后第1天和第2天测量肿胀和张口受限情况。收集唾液，采用夹心ELISA试验测量术前和术后唾液免疫球蛋白A（sIgA）浓度。研究样本包括25例患者（平均年龄22.88岁），共50颗双侧对称的IMTMs。两组术后2小时疼痛程度最高，随时间逐渐降低（<0.01）。48小时时的肿胀和张口受限高于24小时（<0.01）。术后48小时内，PBMT组的疼痛程度、肿胀和张口受限明显较低（<0.05）。PBMT组术后sIgA也明显较低（<0.05）。在本研究的短期和特定条件下，发现PBMT有助于促进IMTMs拔除术后的疼痛缓解和抗炎作用。结果表明，PBMT后唾液sIgA水平降低与炎症过程减轻之间可能存在联系。试验注册号：ClinicalTrials.gov上的NCT04280809。
