通过生育力测试检测雄性小鼠可遗传易位的策略。

Strategies for detecting heritable translocations in male mice by fertility testing.

作者信息

Wiemann H, Lang R

出版信息

Mutat Res. 1978 Jun;53(3):317-26. doi: 10.1016/0165-1161(78)90004-3.

Abstract

Data from a heritable translocation test were analysed to estimate the best rule for classification of F1 males in normals or partially sterile translocation carriers according to litter size or numbers of live and dead implants per mating. Six rules were compared for classification with up to three litter sizes per F1 male observed. The results indicate that a translocation rate of 2%, or at best of 1%, can be detected with reasonable cost.

摘要

对一项可遗传易位试验的数据进行了分析，以根据每窝仔数或每次交配时存活和死亡植入物的数量，估算出将F1雄性分为正常或部分不育易位携带者的最佳规则。比较了六条规则用于分类，每个F1雄性最多观察三窝仔数。结果表明，以合理的成本可以检测到2%或至多1%的易位率。