Department of Neurophysiology, Institute of Physiology, University of Würzburg, 97070 Würzburg, Germany.
Department of Neurophysiology, Institute of Physiology, University of Würzburg, 97070 Würzburg, Germany.
Cell Rep. 2022 Mar 29;38(13):110568. doi: 10.1016/j.celrep.2022.110568.
GABAergic signaling provides inhibitory stabilization and spatiotemporally coordinates the firing of recurrently connected excitatory neurons in mature cortical circuits. Inhibition thus enables self-generated neuronal activity patterns that underlie various aspects of sensation and cognition. In this review, we aim to provide a conceptual framework describing how and when GABA-releasing interneurons acquire their network functions during development. Focusing on the developing visual neocortex and hippocampus in mice and rats in vivo, we hypothesize that at the onset of patterned activity, glutamatergic neurons are stable by themselves and inhibitory stabilization is not yet functional. We review important milestones in the development of GABAergic signaling and illustrate how the cell-type-specific strengthening of synaptic inhibition toward eye opening shapes cortical network dynamics and allows the developing cortex to progressively disengage from extra-cortical synaptic drive. We translate this framework to human cortical development and discuss clinical implications for the treatment of neonatal seizures.
GABA 能信号传递为成熟皮质回路中反复连接的兴奋性神经元提供抑制稳定性，并在时空上协调它们的发射。因此，抑制作用使自我产生的神经元活动模式成为可能，这些模式是感觉和认知各个方面的基础。在这篇综述中，我们旨在提供一个概念框架，描述 GABA 释放中间神经元在发育过程中是如何以及何时获得其网络功能的。我们专注于在体内发育中的小鼠和大鼠的视觉新皮质和海马体，假设在模式化活动开始时，谷氨酸能神经元本身是稳定的，而抑制稳定性尚未发挥功能。我们回顾了 GABA 能信号传递发展中的重要里程碑，并说明了在睁眼时突触抑制的细胞类型特异性增强如何塑造皮质网络动态，并使发育中的皮质能够逐渐脱离皮质外突触驱动。我们将这个框架转化为人类皮质发育，并讨论了新生儿癫痫治疗的临床意义。
