Duggan D B, Schattner A
Am J Med. 1986 Nov;81(5):864-70. doi: 10.1016/0002-9343(86)90359-1.
Manifestations of monoclonal gammopathies are due to four broad mechanisms: destruction of bones, bone marrow, and normal tissues by an expanding tumor; nonspecific effects of large amounts of circulating paraproteins leading to hyperviscosity; autoantibody specificity of paraproteins that give rise to cryoglobulinemia, cold agglutinin disease, and other autoimmune phenomena, as well as incidental binding to bacterial antigens and haptens; and idiopathic syndromes due to as yet unidentified tumor products or other mechanisms. A review with an emphasis on the autoimmune and idiopathic manifestations of monoclonal gammopathies is presented.
不断扩大的肿瘤对骨骼、骨髓和正常组织的破坏；大量循环副蛋白导致血液黏稠度增加的非特异性影响；副蛋白的自身抗体特异性引发冷球蛋白血症、冷凝集素病和其他自身免疫现象，以及与细菌抗原和半抗原的偶然结合；以及由于尚未明确的肿瘤产物或其他机制导致的特发性综合征。本文重点对单克隆丙种球蛋白病的自身免疫和特发性表现进行综述。
