Youinou P, Le Corre R, Dueymes M
Laboratory of Immunology, Brest University Medical School, France.
Clin Exp Rheumatol. 1996 Jan-Feb;14 Suppl 14:S55-8.
Rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren's syndrome are nonorgan-specific autoimmune diseases in which serum monoclonal immunoglobulins (MIg) have been identified repeatedly. Conversely, autoimmune traits have been detected in a number of patients with lymphoproliferative disorders such as multiple myeloma, Waldenström's macroglobulinemia and chronic lymphocytic leukemia. The latter cells have even shown to produce multispecific autoantibodies. One connection between connective tissue diseases and Iymphoid malignancies might be established by a limitedfraction of B Iymphocytes expressing the CD5 marker.
类风湿性关节炎、系统性红斑狼疮和原发性干燥综合征是非器官特异性自身免疫性疾病，其中血清单克隆免疫球蛋白（MIg）已被反复鉴定。相反，在一些淋巴增殖性疾病患者中也检测到了自身免疫特征，如多发性骨髓瘤、华氏巨球蛋白血症和慢性淋巴细胞白血病。后者的细胞甚至已显示能产生多特异性自身抗体。结缔组织疾病和淋巴样恶性肿瘤之间的一种联系可能是由一小部分表达CD5标志物的B淋巴细胞建立的。
