钬: 钇铝石榴石 (Ho:YAG) 激光在上尿路内窥镜手术中产生的温度和热激光损伤: 实验研究的系统评价。
Generated temperatures and thermal laser damage during upper tract endourological procedures using the holmium: yttrium-aluminum-garnet (Ho:YAG) laser: a systematic review of experimental studies.
机构信息
Department of Urology, University Hospital Southampton NHS Trust, Southampton, UK.
Department of Urology and Andrology, General Hospital Hall i.T., Milser Str. 10, 6060, Hall in Tirol, Austria.
出版信息
World J Urol. 2022 Aug;40(8):1981-1992. doi: 10.1007/s00345-022-03992-7. Epub 2022 Mar 31.
PURPOSE
To perform a review on the latest evidence related to generated temperatures during Ho:YAG laser use, and present different tools to maintain decreased values, and minimize complication rates during endourological procedures.
METHODS
We performed a literature search using PubMed, Scopus, EMBASE, and Cochrane Central Register of Controlled Trials-CENTRAL, restricted to original English-written articles, including animal, artificial model, and human studies. Different keywords were URS, RIRS, ureteroscopy, percutaneous, PCNL, and laser.
RESULTS
Thermal dose (t43) is an acceptable tool to assess possible thermal damage using the generated temperature and the time of laser exposure. A t43 value of more than 120 min leads to a high risk of thermal tissue injury and at temperatures higher than 43 °C Ho:YAG laser use becomes hazardous due to an exponentially increased cytotoxic effect. Using open continuous flow, or chilled irrigation, temperatures remain lower than 45 °C. By utilizing high-power (> 40 W) or shorter laser pulse, temperatures rise above the accepted threshold, but adding a ureteral access sheath (UAS) helps to maintain acceptable values.
CONCLUSIONS
Open irrigation systems, chilled irrigation, UASs, laser power < 40 W, and shorter on/off laser activation intervals help to keep intrarenal temperatures at accepted values during URS and PCNL.
目的
对 Ho:YAG 激光使用过程中产生的温度的最新相关证据进行综述,并介绍不同的工具,以维持降低的值,并在经皮肾镜取石术和输尿管镜碎石术等内窥镜手术中降低并发症发生率。
方法
我们使用 PubMed、Scopus、EMBASE 和 Cochrane 中央对照试验注册中心(CENTRAL)进行文献检索,仅限于原创的英文文章,包括动物、人工模型和人体研究。使用了不同的关键词,如 URS、RIRS、输尿管镜检查、经皮、PCNL 和激光。
结果
热剂量(t43)是一种可接受的工具,可通过产生的温度和激光暴露时间来评估可能的热损伤。t43 值大于 120 min 会导致热组织损伤的高风险,而当温度高于 43°C 时,由于细胞毒性作用呈指数增加,Ho:YAG 激光的使用变得危险。使用开放式连续流动或冷却冲洗,温度仍低于 45°C。通过使用高功率(>40 W)或更短的激光脉冲,温度会升高到可接受的阈值以上,但使用输尿管导丝鞘(UAS)有助于维持可接受的温度。
结论
开放式冲洗系统、冷却冲洗、UAS、激光功率<40 W 和更短的激光开启/关闭激活间隔有助于在 URS 和 PCNL 期间将肾内温度保持在可接受的范围内。