Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine, University of Pavia, Pavia, Italy.
Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy.
Drug Test Anal. 2022 Aug;14(8):1417-1428. doi: 10.1002/dta.3265. Epub 2022 Apr 5.
The evaluation of drinking behaviors can help in limiting high-risk situation, such as driving under the influence (DUI). We investigate ethyl glucuronide in hair (hEtG) levels to evaluate alcohol consumption behavior in subjects followed up after having been charged for DUI of psychoactive substances and/or alcohol. We performed a retrospective observational cohort study on 4328 subjects over 18 years old who underwent hEtG analysis in the period 2015-2019 in the Italian Province of Pavia. hEtG level was used as a proxy for the alcohol consumption behavior. Effects of age, sex, and district on alcohol drinking behavior were investigated with an ordinal logit model. A state sequence analysis was used to study people's alcohol consumption behavior over time. hEtG was found ≥7.0 pg/mg in 22.2% of the drivers (of which 7% has an hEtG ≥30.0 pg/mg). Among positive cases, a prevalence of males (96.3%) aged 35-44 (32.6%), coming from main city and hinterland (38.2%), was observed. The propensity to drink was higher for males (odds ratio [OR] ≈ 2.28, p < 0.001) and for subject coming from the district devoted to the cultivation of vineyards. Young age classes have a reduced drinking risk if compared to the drivers over 55 years old (p < 0.001). A general decreasing trend over time in hEtG values was observed. Being male, age ≥ 55 years, and coming from rural areas are potential risk factors related to alcohol drinking habits among drivers. Ethyl glucuronide in hair test in the driving license reissuing protocol contributed to decrease alcohol misuse behaviors.
饮酒行为的评估有助于限制高危情况，如酒后驾车（DUI）。我们研究头发中的乙基葡萄糖醛酸（hEtG）水平，以评估因精神活性物质和/或酒精而被指控 DUI 后接受随访的受试者的饮酒行为。我们对 2015 年至 2019 年期间在意大利帕维亚省接受 hEtG 分析的 4328 名 18 岁以上的受试者进行了回顾性观察队列研究。hEtG 水平被用作评估饮酒行为的替代指标。使用有序逻辑回归模型研究年龄、性别和地区对饮酒行为的影响。使用状态序列分析研究人们随时间的饮酒行为。发现 22.2%的驾驶员（其中 7%的 hEtG ≥ 30.0pg/mg）的 hEtG 水平≥7.0pg/mg。在阳性病例中，观察到男性（96.3%）、35-44 岁（32.6%）、来自主要城市和内陆地区（38.2%）的比例较高。男性（优势比[OR]≈2.28，p<0.001）和来自专门种植葡萄的地区的受试者饮酒的可能性更高。与 55 岁以上的驾驶员相比，年轻年龄组的饮酒风险较低（p<0.001）。随着时间的推移，hEtG 值呈下降趋势。男性、年龄≥55 岁和来自农村地区是与驾驶员饮酒习惯相关的潜在危险因素。在驾驶执照续发过程中进行头发乙基葡萄糖醛酸检测有助于减少酒精滥用行为。
