Zhitny Vladislav Pavlovich, Lyons Mitchell, Perloff Andrea, Menezes John, Pistorio Ashley, Baynosa Richard
Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, NV, USA.
Department of Plastic Surgery, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, NV, USA.
J Surg Case Rep. 2022 Mar 26;2022(3):rjac095. doi: 10.1093/jscr/rjac095. eCollection 2022 Mar.
SARS-CoV-2 manifestations have been an ongoing evolving topic that has spread beyond its initial respiratory associations. Recently, there have been reports of COVID-19 infections found to be associated with vascular pathologies. Here, we describe a case of a fully vaccinated COVID-19 adult male with past medical history of purpura fulminans that presented with diffuse necrotic cutaneous tissue sequelae resulting in intensive care unit management and dry gangrene of upper extremity. On admission, it was found that the patient had decreased activity rather than quantity of coagulation pathway protein S. Early recognition and work up are essential in patients with known history of vascular disease and confirmed cases of SARS-CoV-2 positive polymerase chain reaction.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的表现一直是一个不断演变的话题，其影响已超出最初与呼吸道的关联。最近，有报道称2019冠状病毒病（COVID-19）感染与血管病变有关。在此，我们描述一例完全接种疫苗的COVID-19成年男性病例，其既往有暴发性紫癜病史，出现弥漫性坏死性皮肤组织后遗症，导致入住重症监护病房并出现上肢干性坏疽。入院时发现，患者凝血途径蛋白S的活性而非数量降低。对于有血管疾病已知病史且严重急性呼吸综合征冠状病毒2聚合酶链反应确诊为阳性的患者，早期识别和检查至关重要。
