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两例新型冠状病毒肺炎相关肺曲霉病(CAPA)。

Two cases of COVID-19-associated pulmonary aspergillosis (CAPA).

作者信息

Lim Jin Lee, Khor Inn Shih, Moh Cheng Keat, Chan Yi Min, Lam Yoke Fong, Lachmanan Kumaresh Raj

机构信息

Department of Respiratory Medicine Hospital Raja Permaisuri Bainun Ipoh Malaysia.

Department of Internal Medicine Hospital Raja Permaisuri Bainun Ipoh Malaysia.

出版信息

Respirol Case Rep. 2022 Mar 27;10(4):e0940. doi: 10.1002/rcr2.940. eCollection 2022 Apr.

Abstract

COVID-19-associated pulmonary aspergillosis (CAPA) is a recently recognized entity associated with the COVID-19 pandemic and known post-viral pneumonia complications. More data are awaited and there has been a recent consensus criteria published hoping to generate more research and registries to inform clinical decision-making. Nevertheless, it is clear that CAPA imposes a worsening disease course of COVID-19 pneumonia with added morbidity and mortality. We present two cases with differing outcomes managed within the limitations of our institute and make reference to the recent consensus criteria. We hope to highlight the importance of considering empirical treatment in the correct clinical context while awaiting the results of microbiological workup as ascertaining the diagnosis of proven CAPA is challenging in the real-world setting.

摘要

新型冠状病毒肺炎相关肺曲霉病(CAPA)是一种最近才被认识到的疾病实体,与新型冠状病毒肺炎大流行及已知的病毒性肺炎后并发症相关。更多数据仍有待获取,最近已发布了共识标准,希望能开展更多研究并建立登记系统,为临床决策提供依据。尽管如此,很明显,CAPA会使新型冠状病毒肺炎的病程恶化,增加发病率和死亡率。我们介绍了在本机构的条件限制下处理的两例结局不同的病例,并参考了最近的共识标准。我们希望强调在等待微生物检查结果的同时,在正确的临床背景下考虑经验性治疗的重要性,因为在现实环境中确定确诊的CAPA诊断具有挑战性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7453/8958244/f88d21b1461d/RCR2-10-e0940-g002.jpg

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