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Beyond medications: is pulmonary artery denervation the answer for pulmonary arterial hypertension?: PADN for PAH.

作者信息

Guo Fan, Jing Zhi-Cheng

机构信息

Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

AsiaIntervention. 2022 Mar;8(1):14-15. doi: 10.4244/AIJ-E-22-00001. Epub 2022 Mar 15.

DOI:10.4244/AIJ-E-22-00001
PMID:35355849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8932649/
Abstract
摘要

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1
Beyond medications: is pulmonary artery denervation the answer for pulmonary arterial hypertension?: PADN for PAH.药物治疗之外：肺动脉去神经支配是肺动脉高压的答案吗？：用于肺动脉高压的肺动脉去神经支配术
AsiaIntervention. 2022 Mar;8(1):14-15. doi: 10.4244/AIJ-E-22-00001. Epub 2022 Mar 15.
2
Hemodynamic, functional, and clinical responses to pulmonary artery denervation in patients with pulmonary arterial hypertension of different causes: phase II results from the Pulmonary Artery Denervation-1 study.不同病因肺动脉高压患者对肺动脉去神经支配的血流动力学、功能及临床反应：肺动脉去神经支配-1研究的II期结果
Circ Cardiovasc Interv. 2015 Nov;8(11):e002837. doi: 10.1161/CIRCINTERVENTIONS.115.002837.
3
Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomized PADN-CFDA Trial.肺动脉去神经术治疗肺动脉高压：一项假手术对照、随机的 PADN-CFDA 试验。
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Treatment effects of pulmonary artery denervation for pulmonary arterial hypertension stratified by REVEAL risk score: Results from PADN-CFDA trial.肺动脉去神经术治疗肺动脉高压的效果分层：REVEAL 风险评分结果来自 PADN-CFDA 试验。
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Pulmonary artery denervation to treat pulmonary arterial hypertension: the single-center, prospective, first-in-man PADN-1 study (first-in-man pulmonary artery denervation for treatment of pulmonary artery hypertension).肺动脉去神经术治疗肺动脉高压：单中心、前瞻性、首例人体 PADN-1 研究（首例人体肺动脉去神经术治疗肺动脉高压）。
J Am Coll Cardiol. 2013 Sep 17;62(12):1092-1100. doi: 10.1016/j.jacc.2013.05.075. Epub 2013 Jul 10.
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Pulmonary Artery Denervation: Update on Clinical Studies.肺动脉去神经术：临床研究进展。
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Sympathetic innervation of canine pulmonary artery and morphometric and functional analysis in dehydromonocrotaline-induced models after pulmonary artery denervation.去交感神经支配犬肺动脉后脱水单硝酸野百合碱诱导肺动脉模型的形态计量学和功能分析。
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Pericardial effusion is correlated with clinical outcome after pulmonary artery denervation for pulmonary arterial hypertension.心包积液与肺动脉去神经术治疗肺动脉高压后的临床结局相关。
Oncotarget. 2016 Dec 20;8(33):54106-54114. doi: 10.18632/oncotarget.14031. eCollection 2017 Aug 15.
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Pulmonary Artery Denervation as an Innovative Treatment for Pulmonary Hypertension With and Without Heart Failure.肺动脉去神经支配作为一种创新的治疗方法，用于治疗伴有和不伴有心力衰竭的肺动脉高压。
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Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system.肺动脉去神经支配通过调节局部肾素-血管紧张素-醛固酮系统改善肺动脉高压诱导的右心室功能障碍。
BMC Cardiovasc Disord. 2016 Oct 10;16(1):192. doi: 10.1186/s12872-016-0366-4.

本文引用的文献

1
Long-term mortality after pulmonary artery denervation stratified by baseline functional class in patients with pulmonary arterial hypertension: Long-term mortality after PADN stratified by functional class.肺动脉去神经支配术后长期死亡率按肺动脉高压患者基线功能分级分层：肺动脉去神经支配术后长期死亡率按功能分级分层。
AsiaIntervention. 2022 Mar;8(1):58-68. doi: 10.4244/AIJ-D-21-00033. Epub 2022 Mar 15.
2
Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension.经胸肺动脉去神经术治疗肺动脉高压。
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):704-718. doi: 10.1161/ATVBAHA.118.311992.
3
Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.肺动脉去神经支配可减轻脱氢单硝酸异山梨酯诱导肺动脉高压犬的肺动脉重塑。
JACC Cardiovasc Interv. 2015 Dec 28;8(15):2013-2023. doi: 10.1016/j.jcin.2015.09.015.
4
Pulmonary artery denervation to treat pulmonary arterial hypertension: the single-center, prospective, first-in-man PADN-1 study (first-in-man pulmonary artery denervation for treatment of pulmonary artery hypertension).肺动脉去神经术治疗肺动脉高压：单中心、前瞻性、首例人体 PADN-1 研究（首例人体肺动脉去神经术治疗肺动脉高压）。
J Am Coll Cardiol. 2013 Sep 17;62(12):1092-1100. doi: 10.1016/j.jacc.2013.05.075. Epub 2013 Jul 10.
5
Percutaneous pulmonary artery denervation completely abolishes experimental pulmonary arterial hypertension in vivo.经皮肺动脉去神经支配术可完全消除体内实验性肺动脉高压。
EuroIntervention. 2013 Jun 22;9(2):269-76. doi: 10.4244/EIJV9I2A43.
6
Experimental pulmonary hypertension produced by surgical and chemical denervation of the pulmonary vasculature.通过对肺血管进行手术和化学去神经支配产生的实验性肺动脉高压。
Chest. 1980 Apr;77(4):525-30. doi: 10.1378/chest.77.4.525.
7
Fine structural study of the terminal effecror plexus, neuromuscular and intermuscular relationships in the pulmonary artery.肺动脉终末效应器丛、神经肌肉及肌间关系的超微结构研究
J Anat. 1968 Jun;103(Pt 1):49-63.