Juratsch C E, Jengo J A, Castagna J, Laks M M
Chest. 1980 Apr;77(4):525-30. doi: 10.1378/chest.77.4.525.
The purpose of this study was to investigate the hypothesis that balloon distention of the main pulmonary artery (MPA) induces pulmonary hypertension that is produced by a neural reflex and to investigate the possible efferent components of its reflex arc. Using a specially designed triple-lumen balloon catheter, positioned under fluoroscopy in the MPA, the hemodynamic responses to MPA distention were studied before and after the following: surgical denervation of the bifurcation of the MPA, chemical sympathectomy (6-hydroxydopamine), 100 percent oxygen breathing, and vagotomy. Our findings suggest that the experimental pulmonary hypertension caused by distention of the MPA is produced by excitation of stretch receptors in or near the bifurcation of the MPA and that the efferent limb of this reflex is predominantly mediated via the adrenergic nervous system.
主肺动脉（MPA）球囊扩张会诱发由神经反射产生的肺动脉高压，并研究其反射弧可能的传出成分。使用一种特别设计的三腔球囊导管，在荧光透视引导下将其置于MPA内，在以下操作前后研究对MPA扩张的血流动力学反应：MPA分叉处手术去神经、化学交感神经切除术（6-羟基多巴胺）、100%吸氧和迷走神经切断术。我们的研究结果表明，由MPA扩张引起的实验性肺动脉高压是由MPA分叉处或其附近的牵张感受器兴奋所产生的，并且该反射的传出支主要通过肾上腺素能神经系统介导。
