Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2022 Mar 10;13:847699. doi: 10.3389/fimmu.2022.847699. eCollection 2022.
The NF-κB transcription factor family controls the transcription of many genes and regulates a number of pivotal biological processes. Its activity is regulated by the IκB family of proteins. Bcl-3 is an atypical member of the IκB protein family that regulates the activity of nuclear factor NF-κB. It can promote or inhibit the expression of NF-κB target genes according to the received cell type and stimulation, impacting various cell functions, such as proliferation and differentiation, induction of apoptosis and immune response. Bcl-3 is also regarded as an environment-dependent cell response regulator that has dual roles in the development of B cells and the differentiation, survival and proliferation of Th cells. Moreover, it also showed a contradictory role in inflammation. At present, in addition to the work aimed at studying the molecular mechanism of Bcl-3, an increasing number of studies have focused on the effects of Bcl-3 on inflammation, immunity and malignant tumors . In this review, we focus on the latest progress of Bcl-3 in the regulation of the NF-κB pathway and its extensive physiological role in inflammation and immune cells, which may help to provide new ideas and targets for the early diagnosis or targeted treatment of various inflammatory diseases, immunodeficiency diseases and malignant tumors.
NF-κB 转录因子家族控制着许多基因的转录，并调节许多关键的生物学过程。其活性受 IκB 蛋白家族的调节。Bcl-3 是 IκB 蛋白家族的一个非典型成员，它调节核因子 NF-κB 的活性。它可以根据所接收的细胞类型和刺激来促进或抑制 NF-κB 靶基因的表达，从而影响各种细胞功能，如增殖和分化、凋亡诱导和免疫反应。Bcl-3 也被认为是一种依赖于环境的细胞反应调节剂，在 B 细胞的发育以及 Th 细胞的分化、存活和增殖中具有双重作用。此外，它在炎症中也表现出矛盾的作用。目前，除了旨在研究 Bcl-3 分子机制的工作外，越来越多的研究集中在 Bcl-3 对炎症、免疫和恶性肿瘤的影响上。在这篇综述中，我们重点介绍了 Bcl-3 在调节 NF-κB 通路及其在炎症和免疫细胞中的广泛生理作用方面的最新进展，这可能有助于为各种炎症性疾病、免疫缺陷疾病和恶性肿瘤的早期诊断或靶向治疗提供新的思路和靶点。
