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动脉粥样硬化治疗的最新进展：关键靶点与斑块定位递送策略。

Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies.

作者信息

Li Li, Liu Sainan, Tan Jianying, Wei Lai, Wu Dimeng, Gao Shuai, Weng Yajun, Chen Junying

机构信息

Key Laboratory of Advanced Technology of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, PR China.

Chengdu Daxan Innovative Medical Tech. Co., Ltd., Chengdu, PR China.

出版信息

J Tissue Eng. 2022 Mar 24;13:20417314221088509. doi: 10.1177/20417314221088509. eCollection 2022 Jan-Dec.

DOI:10.1177/20417314221088509
PMID:35356091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8958685/
Abstract

Atherosclerosis, a chronic inflammatory disease of vascular wall, is a progressive pathophysiological process with lipids oxidation/depositing initiation and innate/adaptive immune responses. The coordination of multi systems covering oxidative stress, dysfunctional endothelium, diseased lipid uptake, cell apoptosis, thrombotic and pro-inflammatory responding as well as switched SMCs contributes to plaque growth. In this circumstance, inevitably, targeting these processes is considered to be effective for treating atherosclerosis. Arriving, retention and working of payload candidates mediated by targets in lesion direct ultimate therapeutic outcomes. Accumulating a series of scientific studies and clinical practice in the past decades, lesion homing delivery strategies including stent/balloon/nanoparticle-based transportation worked as the potent promotor to ensure a therapeutic effect. The objective of this review is to achieve a very brief summary about the effective therapeutic methods cooperating specifical targets and positioning-delivery strategies in atherosclerosis for better outcomes.

摘要

动脉粥样硬化是一种血管壁的慢性炎症性疾病，是一个始于脂质氧化/沉积以及先天性/适应性免疫反应的进行性病理生理过程。涵盖氧化应激、功能失调的内皮、异常的脂质摄取、细胞凋亡、血栓形成和促炎反应以及转化的平滑肌细胞等多系统的协同作用促进了斑块生长。在这种情况下，不可避免地，针对这些过程被认为对治疗动脉粥样硬化有效。有效载荷候选物由病变中的靶点介导到达、滞留并发挥作用，直接决定最终治疗效果。在过去几十年积累的一系列科学研究和临床实践中，包括基于支架/球囊/纳米颗粒的运输在内的病变归巢递送策略成为确保治疗效果的有力促进因素。本综述的目的是对在动脉粥样硬化中结合特定靶点和定位递送策略以获得更好疗效的有效治疗方法进行非常简要的总结。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/d921ab6651ae/10.1177_20417314221088509-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/5a97f546baaa/10.1177_20417314221088509-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/dd5e7844360d/10.1177_20417314221088509-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/e49a01986748/10.1177_20417314221088509-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/46ac725d45c7/10.1177_20417314221088509-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/a9790cf1cf5b/10.1177_20417314221088509-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/c5f1085fb054/10.1177_20417314221088509-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/00dea719ee8f/10.1177_20417314221088509-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/747ee8e158c8/10.1177_20417314221088509-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/d921ab6651ae/10.1177_20417314221088509-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/5a97f546baaa/10.1177_20417314221088509-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/a75a686a52fa/10.1177_20417314221088509-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/c24d53d1d996/10.1177_20417314221088509-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/dd5e7844360d/10.1177_20417314221088509-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/e49a01986748/10.1177_20417314221088509-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/46ac725d45c7/10.1177_20417314221088509-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/a9790cf1cf5b/10.1177_20417314221088509-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/c5f1085fb054/10.1177_20417314221088509-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/00dea719ee8f/10.1177_20417314221088509-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/747ee8e158c8/10.1177_20417314221088509-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0feb/8958685/d921ab6651ae/10.1177_20417314221088509-fig11.jpg

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