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与自身免疫性胃炎相关的混合性神经内分泌-非神经内分泌肿瘤

Mixed neuroendocrine-non-neuroendocrine neoplasm associated with autoimmune gastritis.

作者信息

Mori Naoko, Hongo Masanori, Takemura Shizuki, Sugitani Yoshihiko, Nakamura Fumiyasu, Tani Masaji, Nishida Atsushi, Inatomi Osamu, Andoh Akira, Ban Hiromitsu

机构信息

Division of Gastroenterology Omi Medica Center Shiga Japan.

Division of Pathology Omi Medica Center Shiga Japan.

出版信息

Clin Case Rep. 2022 Mar 22;10(3):e05640. doi: 10.1002/ccr3.5640. eCollection 2022 Mar.

DOI:10.1002/ccr3.5640
PMID:35356166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8940597/
Abstract

A 60-year-old woman presented with a protruding tumor at the anterior wall of the middle gastric body, and she was positive for anti-parietal cells antibodies with elevated serum gastrin level. Final diagnosis was a mixed neuroendocrine-non-neuroendocrine neoplasm consisting of adenocarcinoma (tub1) and neuroendocrine tumor G2 with autoimmune gastritis.

摘要

一名60岁女性因胃体中部前壁有一突出肿瘤就诊，抗壁细胞抗体阳性，血清胃泌素水平升高。最终诊断为混合性神经内分泌-非神经内分泌肿瘤，由腺癌（tub1）和神经内分泌肿瘤G2组成，并伴有自身免疫性胃炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/dcc7a46fda81/CCR3-10-e05640-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/e11c8acb0125/CCR3-10-e05640-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/3488ba8ff827/CCR3-10-e05640-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/dcc7a46fda81/CCR3-10-e05640-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/e11c8acb0125/CCR3-10-e05640-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/3488ba8ff827/CCR3-10-e05640-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1add/8940597/dcc7a46fda81/CCR3-10-e05640-g002.jpg

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本文引用的文献

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2
The new WHO classification of gastrointestinal neuroendocrine tumors and immunohistochemical expression of somatostatin receptor 2 and 5.世界卫生组织胃肠道神经内分泌肿瘤新分类以及生长抑素受体2和5的免疫组化表达
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Clinicopathologic and Molecular Characteristics of Gastrointestinal MiNENs.
胃肠道混合性神经内分泌-非神经内分泌肿瘤的临床病理及分子特征
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Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients.自身免疫性胃炎中的幽门、假幽门和舒血管肠肽表达化生：22 例日本患者的病例系列。
Virchows Arch. 2021 Jul;479(1):169-178. doi: 10.1007/s00428-021-03033-5. Epub 2021 Jan 30.
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Neuroendocrine neoplasia of the gastrointestinal tract revisited: towards precision medicine.胃肠道神经内分泌肿瘤再探讨：迈向精准医学。
Nat Rev Endocrinol. 2020 Oct;16(10):590-607. doi: 10.1038/s41574-020-0391-3. Epub 2020 Aug 24.
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United European Gastroenterol J. 2020 Mar;8(2):175-184. doi: 10.1177/2050640619891580. Epub 2019 Nov 26.
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