Department of Transfusion Medicine, Post Graduate Institute of Child Health (PGICH), Noida, Uttar Pradesh, India.
Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer, Institute at SIU School of Medicine, Springfield, Illinois, USA.
Transfusion. 2022 May;62(5):1000-1009. doi: 10.1111/trf.16857. Epub 2022 Mar 31.
Blood centers play a critical role in supporting neonatal and pediatric transfusions. We aim to study the variation in pediatric/neonatal transfusion policies and practices for blood centers in India.
This is a survey-based (45 question) cross-sectional assessment of blood centers in India supporting pediatric/neonatal transfusions.
One hundred three centers responded to the survey (response rate 51.2%; 103/201). As a part of pretransfusion testing, use of "microtainers" was reported by 58.4% (59/101) centers and only 57.4% (58/101) centers provide antibody screening. In case of absence of maternal sample, type O negative blood is most commonly used (48.5%; 49/101), and in case of ABO incompatibility, 68.3% (69/101) use units compatible with both mother and newborn. Leukoreduced RBCs are provided by 89% (90/101) centers and irradiated products are provided by 48.5% (49/101). 82% (83/101) of centers reported not receiving requests for CMV negative units considering the high incidence of CMV-seropositivity in donors. Fresh units are defined as <7 days old by 44.5% (45/101) and <5 days old by 31.6% (32/101) centers. 97% centers reported SAGM suspended RBCs in inventory but only 67.3% (68/101) use them for top-up transfusions to neonates. Overall >80% centers use the buffy-coat method for platelet concentrates preparation. Volume-based (ml/kg) aliquots preparation is done by 88% (89/101), mainly using the sterile connecting device (84.6%; 83/98).
This survey shows heterogeneity and lack of standardization in practices across blood centers in India and highlights the need for more studies to establish best practices for this vulnerable age group.
血站在支持新生儿和儿科输血方面发挥着关键作用。我们旨在研究印度血站在儿科/新生儿输血政策和实践方面的差异。
这是一项针对支持儿科/新生儿输血的印度血站的基于调查（45 个问题）的横断面评估。
共有 103 个中心对调查做出了回应（回应率为 51.2%；103/201）。作为输血前检测的一部分，58.4%（59/101）的中心报告使用“微量管”，只有 57.4%（58/101）的中心提供抗体筛查。在没有母亲样本的情况下，最常使用 O 型阴性血（48.5%；49/101），在 ABO 不相容的情况下，68.3%（69/101）使用与母亲和新生儿都相容的单位。89%（90/101）的中心提供去白细胞的红细胞，48.5%（49/101）的中心提供辐照产品。82%（83/101）的中心报告没有收到 CMV 阴性单位的请求，因为供体中 CMV 血清阳性的发生率很高。44.5%（45/101）的中心将新鲜单位定义为<7 天，31.6%（32/101）的中心将新鲜单位定义为<5 天。97%的中心报告库存中有 SAGM 悬浮红细胞，但只有 67.3%（68/101）将其用于新生儿的补充输血。总体而言，超过 80%的中心使用白细胞去除法制备血小板浓缩物。88%（89/101）的中心使用基于体积（ml/kg）的等分制备，主要使用无菌连接装置（84.6%；83/98）。
这项调查显示了印度血站在实践方面的异质性和缺乏标准化，突出了需要更多的研究来为这个脆弱的年龄组建立最佳实践。
