使用 3D 超短回波时间锥形绝热 T（3D UTE-Cones-AdiabT）成像定量评估关节软骨退变。
Quantitative assessment of articular cartilage degeneration using 3D ultrashort echo time cones adiabatic T (3D UTE-Cones-AdiabT) imaging.
机构信息
Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Department of Radiology, University of California San Diego, 9452 Medical Center Dr., San Diego, CA, 92037, USA.
出版信息
Eur Radiol. 2022 Sep;32(9):6178-6186. doi: 10.1007/s00330-022-08722-6. Epub 2022 Mar 31.
OBJECTIVES
To evaluate articular cartilage degeneration using quantitative three-dimensional ultrashort-echo-time cones adiabatic-T (3D UTE-Cones-AdiabT) imaging.
METHODS
Sixty-six human subjects were recruited for this study. Kellgren-Lawrence (KL) grade and Whole-Organ Magnetic-Resonance-Imaging Score (WORMS) were evaluated by two musculoskeletal radiologists. The human subjects were categorized into three groups, namely normal controls (KL0), doubtful-minimal osteoarthritis (OA) (KL1-2), and moderate-severe OA (KL3-4). WORMS were regrouped to encompass the extent of lesions and the depth of lesions. The UTE-Cones-AdiabT values were obtained using 3D UTE-Cones data acquisitions preceded by seven paired adiabatic full passage pulses that corresponded to seven spin-locking times (TSLs) of 0, 12, 24, 36, 48, 72, and 96 ms. The performance of the UTE-Cones-AdiabT technique in evaluating the degeneration of knee cartilage was assessed via the ANOVA comparisons with subregional analysis and Spearman's correlation coefficient as well as the receiver-operating-characteristic (ROC) curve.
RESULTS
UTE-Cones-AdiabT showed significant positive correlations with KL grade (r = 0.15, p < 0.05) and WORMS (r = 0.57, p < 0.05). Higher UTE-Cones-AdiabT values were observed in both larger and deeper lesions in the cartilage. The differences in UTE-Cones-AdiabT values among different extent and depth groups of cartilage lesions were all statistically significant (p < 0.05). Subregional analyses showed that the correlations between UTE-Cones-AdiabT and WORMS varied with the location of cartilage. The AUC value of UTE-Cones-AdiabT for mild cartilage degeneration (WORMS=1) was 0.8. The diagnostic threshold value of UTE-Cones-AdiabT for mild cartilage degeneration was 39.4 ms with 80.8% sensitivity.
CONCLUSIONS
The 3D UTE-Cones-AdiabT sequence can be useful in quantitative evaluation of articular cartilage degeneration.
KEY POINTS
• The 3D UTE-Cones-AdiabT sequence can distinguish mild cartilage degeneration from normal cartilage with a diagnostic threshold value of 39.4 ms for mild cartilage degeneration with 80.8% sensitivity. • Higher UTE-Cones-AdiabT values were observed in both larger and deeper lesions in the articular cartilage. • UTE-Cones-AdiabT is a promising biomarker for quantitative evaluation of early cartilage degeneration.
目的
使用定量三维超短回波时间锥形绝热 T（3D UTE-Cones-AdiabT）成像评估关节软骨退变。
方法
本研究纳入 66 名受试者。两名肌肉骨骼放射科医生评估了 Kellgren-Lawrence（KL）分级和全器官磁共振成像评分（WORMS）。受试者分为三组，即正常对照组（KL0）、可疑-轻度骨关节炎（OA）（KL1-2）和中重度 OA（KL3-4）。WORMS 被重新分组以包含病变程度和病变深度。使用 3D UTE-Cones 数据采集获得 UTE-Cones-AdiabT 值，该采集之前进行了七次配对绝热全通过脉冲，对应七个自旋锁定时间（TSL）为 0、12、24、36、48、72 和 96 ms。通过 ANOVA 比较、亚区分析和 Spearman 相关系数以及受试者工作特征（ROC）曲线评估 UTE-Cones-AdiabT 技术在评估膝关节软骨退变中的性能。
结果
UTE-Cones-AdiabT 与 KL 分级（r = 0.15，p < 0.05）和 WORMS（r = 0.57，p < 0.05）呈显著正相关。软骨中较大和较深的病变部位的 UTE-Cones-AdiabT 值较高。软骨病变不同程度和深度组之间的 UTE-Cones-AdiabT 值差异均具有统计学意义（p < 0.05）。亚区分析显示，UTE-Cones-AdiabT 与 WORMS 之间的相关性随软骨位置而变化。UTE-Cones-AdiabT 对轻度软骨退变（WORMS=1）的 AUC 值为 0.8。UTE-Cones-AdiabT 对轻度软骨退变的诊断阈值为 39.4 ms，敏感性为 80.8%。
结论
3D UTE-Cones-AdiabT 序列可用于关节软骨退变的定量评估。
Zotero 插件