Université de Lorraine, CITHEFOR, Nancy, F-54000, France.
Institut National de la Santé et de la Recherche Médicale, Inserm UMR_S 1121 Biomaterials and Bioengineering, Strasbourg, F-67085, France.
Adv Healthc Mater. 2022 Jul;11(13):e2102692. doi: 10.1002/adhm.202102692. Epub 2022 Apr 13.
An overview on the design of nitric oxide (NO) delivering surfaces for biomedical purposes is provided, with a focus on the advances of the past 5 years. A localized supply of NO is of a particular interest due to the pleiotropic biological effects of this diatomic compound. Depending on the generated NO flux, the surface can mimic a physiological release profile to provide an activity on the vascular endothelium or an antibacterial activity. Three requirements are considered to describe the various strategies leading to a surface delivering NO. Firstly, the coating must be selected in accordance with the properties of the substrate (nature, shape, dimensions…). Secondly, the releasing and/or generating kinetics of NO should match the targeted biological application. Currently, the most promising structures are developed to provide an adaptable NO supply driven by pathophysiological needs. Finally, the biocompatibility and the stability of the surface must also be considered regarding the expected residence time of the device. A critical point of view is proposed to help readers in the design of the NO delivering surface according to its expected requirement and therapeutic purpose.
提供了用于生物医学目的的一氧化氮（NO）输送表面的设计概述，重点介绍了过去 5 年的进展。由于这种双原子化合物的多种生物学效应，局部供应 NO 特别有趣。根据产生的 NO 通量，表面可以模拟生理释放曲线，从而在血管内皮细胞上提供活性或抗菌活性。为了描述导致表面输送 NO 的各种策略，考虑了三个要求。首先，必须根据基底的性质（性质、形状、尺寸等）选择涂层。其次，NO 的释放和/或生成动力学应与靶向生物应用相匹配。目前，最有前途的结构是为满足病理生理需求而开发的，可提供适应性 NO 供应。最后，还必须考虑表面的生物相容性和稳定性，以及器械的预期留置时间。提出了一个关键观点，以帮助读者根据预期要求和治疗目的设计输送 NO 的表面。
