Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China; Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, 511443, Guangzhou, China.
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China.
Environ Res. 2022 Sep;212(Pt A):113129. doi: 10.1016/j.envres.2022.113129. Epub 2022 Mar 29.
Epidemiological evidence suggests potential associations of road traffic noise exposure with cardiovascular disease (CVD) and mortality, but uncertainty remains.
We examined the association of road traffic noise with the risk of CVD and mortality in a large longitudinal cohort study and meta-analysis.
We analyzed 342, 566 participants from the UK Biobank who were free of CVD at baseline and had complete covariate data. We also performed a meta-analysis of road traffic noise effects on CVD and mortality by including qualified cohort studies published before April 2021.
After adjustment for potential confounders, the odds for the risk of stroke, CVD, and all-cause mortality increased by 1.07 (95%CI: 1.01-1.13, P = 0.019), 1.13 (95%CI: 1.04-1.22, P = 0.003) and 1.08 (95%CI: 1.04-1.12, P < 0.001) times per 10 dB increases in road traffic noise, respectively. Among men, high road traffic noise exposure was significantly associated with an increased risk in stroke (HR = 1.08 per 10 dB increase, 95%CI: 1.00-1.16, P = 0.043), CVD (HR = 1.12 per 10 dB increase, 95%CI: 1.02-1.23, P = 0.020) and all-cause mortality (HR = 1.12 per 10 dB increase, 95%CI: 1.07-1.17 P < 0.001), whereas we did not find a significant association in women. The meta-analysis showed that road traffic noise exposure was significantly associated with a high risk of stroke (risk ratio [RR]: 1.06, 95% CI: 1.02-1.11), CVD mortality (RR: 1.03, 95% CI: 1.00-1.05), all-cause mortality (RR: 1.05, 95% CI: 1.02-1.07).
This study provides more evidence of increased risk of stroke, CVD, and all-cause mortality in association with exposure to road traffic noise pollution, especially in men.
流行病学证据表明，道路交通噪声暴露与心血管疾病 (CVD) 和死亡率之间存在潜在关联，但仍存在不确定性。
我们在一项大型纵向队列研究和荟萃分析中研究了道路交通噪声与 CVD 风险和死亡率的关系。
我们分析了英国生物库中 342566 名基线时无 CVD 且具有完整协变量数据的参与者。我们还通过纳入 2021 年 4 月前发表的合格队列研究，对道路交通噪声对 CVD 和死亡率的影响进行了荟萃分析。
在调整潜在混杂因素后，道路交通噪声每增加 10dB，中风、CVD 和全因死亡率的风险分别增加 1.07（95%CI：1.01-1.13，P=0.019）、1.13（95%CI：1.04-1.22，P=0.003）和 1.08（95%CI：1.04-1.12，P<0.001）倍。在男性中，道路交通噪声暴露水平高与中风风险增加显著相关（每增加 10dB 的 HR=1.08，95%CI：1.00-1.16，P=0.043）、CVD（HR=1.12 per 10dB increase，95%CI：1.02-1.23，P=0.020）和全因死亡率（HR=1.12 per 10dB increase，95%CI：1.07-1.17，P<0.001），而在女性中未发现显著相关性。荟萃分析表明，道路交通噪声暴露与中风风险增加显著相关（风险比 [RR]：1.06，95%CI：1.02-1.11）、CVD 死亡率（RR：1.03，95%CI：1.00-1.05）、全因死亡率（RR：1.05，95%CI：1.02-1.07）。
本研究提供了更多证据表明，道路交通噪声污染暴露与中风、CVD 和全因死亡率风险增加相关，尤其是在男性中。
