Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland; Finnish Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland.
Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland; Finnish Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland; Turku PET Centre, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.
Clin Neurophysiol. 2022 May;137:159-176. doi: 10.1016/j.clinph.2022.03.005. Epub 2022 Mar 15.
We investigated early maturation of the infant mismatch response MMR, including mismatch negativity (MMN), positive MMR (P-MMR), and late discriminative negativity (LDN), indexing auditory discrimination abilities, and the influence of familial developmental dyslexia risk.
We recorded MMRs to vowel, duration, and frequency deviants in pseudo-words at 0, 6, and 28 months and compared MMRs in subgroups with vs. without dyslexia risk, in a sample over-represented by risk infants.
Neonatal MMN to the duration deviant became larger and earlier by 28 months; MMN was elicited by more deviants only at 28 months. The P-MMR was predominant in infancy; its amplitude increased by 6 and decreased by 28 months; latency decreased with increasing age. An LDN emerged by 6 months and became larger and later by 28 months. Dyslexia risk affected MMRs and their maturation.
MMRs demonstrate an expected maturational pattern with 2-3 peaks by 28 months. The effects of dyslexia risk are prominent but not always as expected.
This large-scale longitudinal study shows MMR maturation with three age groups and three deviants. Results illuminate MMR's relation to the adult responses, and hence their cognitive underpinnings, and help in identifying typical/atypical auditory development in early childhood.
我们研究了婴儿失配反应（MMR）的早期成熟，包括失匹配负波（MMN）、正失配反应（P-MMR）和晚期辨别负波（LDN），以评估听觉辨别能力，并探讨家族性发展性阅读障碍风险的影响。
我们在 0、6 和 28 个月时记录了对伪词的元音、时长和频率偏差的 MMR，并比较了有和无阅读障碍风险的亚组之间的 MMR，该样本中风险婴儿的比例较高。
新生儿对时长偏差的 MMN 在 28 个月时变得更大且更早；仅在 28 个月时，MMN 可由更多的偏差诱发。P-MMR 在婴儿期占主导地位；其振幅在 6 个月时增加，在 28 个月时减少；潜伏期随年龄增长而缩短。6 个月时出现 LDN，在 28 个月时变得更大且更晚。阅读障碍风险影响 MMR 及其成熟度。
MMR 表现出预期的成熟模式，在 28 个月时有 2-3 个峰值。阅读障碍风险的影响显著，但并不总是预期的那样。
这项大规模纵向研究展示了具有三个年龄组和三个偏差的 MMR 成熟过程。结果阐明了 MMR 与成人反应的关系，从而阐明了其认知基础，并有助于在幼儿期识别典型/异常的听觉发育。
