Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong, China.
TCM Gynecology Department, Foshan Fosun Chancheng Hospital, Chancheng District, Foshan, Guangdong, China.
J Trace Elem Med Biol. 2022 Jul;72:126971. doi: 10.1016/j.jtemb.2022.126971. Epub 2022 Mar 23.
Preeclampsia is the main cause of maternal and perinatal death. Multiple studies suggest that trace elements were associated with preeclampsia, but the results varied, and less known about early or mid-term pregnancy of trace elements and preeclampsia. We aim to explore the association between mid-term pregnancy trace elements levels and preeclampsia.
The retrospective cohort study was consecutively conducted in Foshan Fosun Chancheng Hospital, Guangdong Province, China, from August 1, 2019, to November 30, 2019. Trace elements are derived from the laboratory data system, measured in maternal whole blood during 12-27 (+6) weeks of pregnancy by flame atomic absorption spectrometer method. Preeclampsia diagnosis and covariance were ascertained from the electronic medical records system. We used multivariable logical regression to estimate odds ratios (OR) and 95% CIs.
A total of 2186 participants were included in this study, and 59 (2.70%) women developed preeclampsia. After multivariable adjustment, the OR of Mg levels for preeclampsia was 0.35 (95%CI:0.06,2.20). The fifth quintiles of Mg were associated with 0.29 (95% CI：0.10,0.85) times lower risk of preeclampsia compared with the first quintile, with a dose-response trend (P for trend = 0.056). Per 1 µmol/L increment in Cu was associated with 11% lower risk of preeclampsia (OR=0.89; 95% CI, 0.78,1.02). Compared with the first quintile, the second, third，fourth，fifth quintile of Cu was associated with a odd ratio of 0.12 (95% CI:0.03,0.43),0.67 (95% CI:0.30,1.48),0.33 (95% CI:0.15,0.76) and 0.26 (95% CI:0.10,0.66),respectively. Null associations were observed for Zn, Fe, Ca.
Higher blood Mg and Cu levels in mid-term pregnancy were associated with lower preeclampsia risk.
子痫前期是孕产妇和围生儿死亡的主要原因。多项研究表明，微量元素与子痫前期有关，但结果存在差异，关于孕中期和孕早期微量元素与子痫前期的关系知之甚少。我们旨在探讨孕中期微量元素水平与子痫前期的关系。
这是一项在中国广东省佛山市佛投禅城区中心医院进行的回顾性队列研究，研究时间为 2019 年 8 月 1 日至 2019 年 11 月 30 日。微量元素来源于实验室数据系统，通过火焰原子吸收光谱法在妊娠 12-27（+6）周时测量孕妇全血中的微量元素。子痫前期的诊断和协变量均从电子病历系统中确定。我们使用多变量逻辑回归来估计比值比（OR）和 95%置信区间（CI）。
本研究共纳入 2186 名参与者，其中 59 名（2.70%）女性发生子痫前期。经多变量校正后，Mg 水平与子痫前期的 OR 为 0.35（95%CI：0.06，2.20）。与第 1 五分位数相比，第 5 五分位数的 Mg 与子痫前期的风险降低 0.29（95% CI：0.10，0.85），呈剂量反应趋势（P 趋势=0.056）。Cu 每增加 1µmol/L，子痫前期的风险降低 11%（OR=0.89；95% CI，0.78，1.02）。与第 1 五分位数相比，第 2、3、4、5 五分位数的 Cu 比值比分别为 0.12（95% CI：0.03，0.43）、0.67（95% CI：0.30，1.48）、0.33（95% CI：0.15，0.76）和 0.26（95% CI：0.10，0.66）。Zn、Fe、Ca 与子痫前期均无显著关联。
孕中期血液中较高的 Mg 和 Cu 水平与子痫前期风险降低有关。
