Department of Periodontology, PMNM Dental College and Hospital, Bagalkot, India.
Department of Periodontology, Bapuji Dental College and Hospital, Davangere, India.
Dent Med Probl. 2022 Jan-Mar;59(1):111-119. doi: 10.17219/dmp/139198.
Currently, the knowledge on the clinical effect of 4% mangosteen gel as a local drug delivery, adjunctive to non-surgical periodontal therapy, on the gingival crevicular fluid (GCF) total antioxidant capacity (TAOC) levels in chronic periodontitis patients is limited.
The aim of the study was to evaluate and compare the efficacy of 4% mangosteen gel and a placebo gel as an adjunct to scaling and root planing (SRP) on clinical and biochemical parameters in chronic periodontitis patients.
A total of 50 test sites from 25 patients with Stage II Grade B periodontitis were randomly divided into 2 groups. The experimental group was treated with SRP followed by a single subgingival application of 4% mangosteen gel, while the control group was treated with SRP followed by a single subgingival application of a placebo gel. Clinical parameters, including the plaque index (PI), the gingival bleeding index (GBI), the probing depth (PD), the relative attachment level (RAL), as well as biochemical parameters, i.e., the GCF TAOC levels, were evaluated using an ABTS (2,2'-Azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) antioxidant assay kit at baseline (D0) and at 3 months (D3).
The full-mouth PI and GBI values were significantly lower at D3 in comparison with D3. The experimental sites showed a significantly greater reduction in the PD and RAL scores as compared to control, and the GCF TAOC levels revealed a substantial rise throughout the study period, reversing from negative values at D0 to positive values at D3 in the experimental group.
Traditional SRP with the adjunctive local delivery of 4% mangosteen gel demonstrated an added benefit in improving clinical and biochemical parameters, and thereby encouraging the use of the mangosteen gel in clinical practice for the management of moderate chronic periodontitis.
目前，关于 4%山竹凝胶作为局部药物输送，辅助非手术牙周治疗，对慢性牙周炎患者龈沟液（GCF）总抗氧化能力（TAOC）水平的临床效果的知识有限。
本研究旨在评估和比较 4%山竹凝胶和安慰剂凝胶作为龈下刮治和根面平整（SRP）辅助治疗在慢性牙周炎患者的临床和生化参数方面的疗效。
共纳入 25 名 II 期 B 级牙周炎患者的 50 个试验部位，随机分为两组。实验组采用 SRP 联合单次局部应用 4%山竹凝胶治疗，对照组采用 SRP 联合单次局部应用安慰剂凝胶治疗。采用 ABTS（2,2'-Azino-bis-3-ethylbenzothiazoline-6-sulfonic acid）抗氧化测定试剂盒，在基线（D0）和 3 个月（D3）时评估临床参数，包括菌斑指数（PI）、牙龈出血指数（GBI）、探诊深度（PD）、相对附着水平（RAL），以及生化参数，即 GCF TAOC 水平。
与 D3 相比，D3 时全口 PI 和 GBI 值明显降低。实验组 PD 和 RAL 评分的降低明显大于对照组，GCF TAOC 水平在整个研究期间显著升高，实验组从 D0 的负值转为 D3 的正值。
传统的 SRP 联合局部应用 4%山竹凝胶可改善临床和生化参数，有助于在临床实践中使用山竹凝胶治疗中度慢性牙周炎。
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