Mahendra Jaideep, Mahendra Little, Svedha Priyadharshini, Cherukuri Sandhya, Romanos Georgios E
Department of Periodontology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, India.
Department of Periodontics, Annamalai University, Chidambaram, India.
J Investig Clin Dent. 2017 Nov;8(4). doi: 10.1111/jicd.12262. Epub 2017 Mar 20.
The aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (RCM), such as Treponema denticola (Td), Porphyromonas gingivalis, and Tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (Garcinia mangostana [MGA]) as an adjunct to scaling and root planing (SRP).
Twenty-five patients (MGA group) were treated with SRP, and the subgingival application of mangostana gel was used as local drug delivery. Twenty-five patients (placebo group) were treated with SRP and placebo gel. Clinical parameters were recorded, and the presence of RCM was assessed at baseline and at the third month.
Clinical parameters, such as probing pocket depth, clinical attachment level, bleeding index, plaque index, and Td, were significantly reduced in the MGA group compared to the placebo group from baseline to the third month.
There was a significant improvement in the periodontal status with a reduction in Td with the application of mangostana gel in periodontal pockets. In the near future, 4% mangostana gel can be used as an adjunct to SRP to provide a new dimension to periodontal therapy.
本研究旨在评估牙周炎患者在应用4%山竹果凝胶（莽吉柿[MGA]）辅助龈下刮治和根面平整（SRP）前后，个体的牙周状况以及龈下组织中红色复合体微生物（RCM）的存在情况，如具核梭杆菌（Td）、牙龈卟啉单胞菌和福赛坦纳菌。
25例患者（MGA组）接受SRP治疗，并使用龈下应用山竹果凝胶作为局部给药。25例患者（安慰剂组）接受SRP和安慰剂凝胶治疗。记录临床参数，并在基线和第三个月评估RCM的存在情况。
从基线到第三个月，与安慰剂组相比，MGA组的临床参数，如探诊深度、临床附着水平、出血指数、菌斑指数和Td均显著降低。
应用山竹果凝胶于牙周袋可显著改善牙周状况并减少Td。在不久的将来，4%山竹果凝胶可作为SRP的辅助手段，为牙周治疗提供新的维度。
