Graduate School of Hebei Medical University, Shijiazhuang, China.
Department of Gastrointestinal Surgery, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Folia Neuropathol. 2022;60(1):60-68. doi: 10.5114/fn.2022.114343.
Focal lesion sites can predict the language function of patients with aphasia during the subacute or chronic phases. However, the relationship between focal lesion sites and language deficits in the acute phase remains unclear. Therefore, our study aimed to investigate the relationship between focal lesion sites and fluency, auditory comprehension, repetition and naming deficits in patients with acute aphasia to further understand the pathophysiological mechanism of aphasia.
We included a total of 52 patients with acute aphasia who had their first-ever stroke between June 2018 and June 2021 to investigate the association between focal lesion sites and fluency, auditory comprehension, repetition and naming deficits. Language function was assessed by the Western Aphasia Battery scale within one month of onset. The lesion sites were independently assessed by three professional speech and language pathologists according to the main sulcus of the brain within 1-2 days after stroke.
Lesions involving the superior temporal gyrus, middle frontal gyrus, inferior frontal gyrus, precentral gyrus, postcentral gyrus, supramarginal gyrus, angular gyrus and insula were significantly associated with low fluency. Lesions involving the superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, middle frontal gyrus, inferior frontal gyrus, supramarginal gyrus and angular gyrus significantly resulted in auditory comprehension impairment. Lesions involving the superior temporal gyrus, middle temporal gyrus, middle frontal gyrus, inferior frontal gyrus, precentral gyrus, postcentral gyrus, supramarginal gyrus, angular gyrus and insula significantly resulted in repetition and naming deficits.
Our study suggests that focal lesion sites could lead to different language function impairments in the acute phase of post-stroke aphasia, which adds to our understanding of speech pathology and provides a direction for future research and treatment.
在亚急性期或慢性期，病灶部位可预测失语症患者的语言功能。然而，病灶部位与急性期语言缺陷之间的关系尚不清楚。因此，我们的研究旨在探讨急性失语症患者病灶部位与流畅性、听觉理解、重复和命名缺陷之间的关系，以进一步了解失语症的病理生理机制。
我们共纳入 52 例首次发生于 2018 年 6 月至 2021 年 6 月的急性失语症患者，以探讨病灶部位与流畅性、听觉理解、重复和命名缺陷之间的关系。发病后一个月内通过西方失语症成套测验评估语言功能。发病后 1-2 天内，由 3 名专业言语治疗师根据大脑主要脑沟对病灶部位进行独立评估。
涉及颞上回、额中回、额下回、中央前回、中央后回、缘上回、角回和岛叶的病灶与流畅性降低显著相关。涉及颞上回、颞中回、颞下回、额中回、额下回、缘上回和角回的病灶与听觉理解障碍显著相关。涉及颞上回、颞中回、额中回、额下回、中央前回、中央后回、缘上回、角回和岛叶的病灶与重复和命名缺陷显著相关。
本研究提示病灶部位可导致急性脑卒中后失语症患者出现不同的语言功能障碍，增加了我们对言语病理学的理解，并为未来的研究和治疗提供了方向。
