Capital Medical University School of Rehabilitation Medicine, China.
Department of Clinical Nutrition, Beijing Bo'ai Hospital, China Rehabilitation Research Center, China.
Folia Neuropathol. 2022;60(1):114-121. doi: 10.5114/fn.2022.114347.
To analyse the relationship between 25-hydroxyvitamin D (25(OH)D) level and rehabilitation in stroke patients.
100 stroke patients hospitalized in the Neurorehabilitation Department of China Rehabilitation Research Center from November 2019 to April 2020 were selected as the research subjects. And set up a case group. 50 subjects who underwent outpatient physical examination in China Rehabilitation Research Center in the same period were selected as the control group. The differences of biochemical and bone metabolism indexes such as serum 25(OH)D, blood lipid, liver and kidney function between the two groups were analysed. We took rehabilitation efficacy as the dependent variable, Pearson correlation analysis and multivariate logistic regression analysis were performed to analyse the indicators affecting rehabilitation efficacy.
The average level of 25(OH)D in the case group was significantly lower than that in the control group ( p < 0.05). The rehabilitation efficacy was significantly positively correlated with 25(OH)D level ( p < 0.003) and significantly negatively correlated with duration of disease ( p < 0.01) and NIHSS score ( p < 0.05).
The increase in 25(OH)D is a protective factor for non-occurrence of cerebral infarction, and the increase in the 25(OH)D level is conducive to the prognosis of cerebral infarction.
分析 25-羟维生素 D（25（OH）D）水平与脑卒中患者康复之间的关系。
选取 2019 年 11 月至 2020 年 4 月在中国康复研究中心神经康复科住院的 100 例脑卒中患者作为研究对象，并设立病例组。选取同期在中国康复研究中心门诊体检的 50 例患者作为对照组。分析两组间血清 25（OH）D、血脂、肝肾功能等生化及骨代谢指标的差异。以康复疗效为因变量，采用 Pearson 相关分析及多元 logistic 回归分析对影响康复疗效的指标进行分析。
病例组患者 25（OH）D 平均水平显著低于对照组（p＜0.05）。康复疗效与 25（OH）D 水平呈显著正相关（p＜0.003），与病程（p＜0.01）和 NIHSS 评分（p＜0.05）呈显著负相关。
25（OH）D 水平升高是脑梗死不发生的保护因素，25（OH）D 水平升高有利于脑梗死患者的预后。
