Yang Huarong, Wu Qinhua, Zheng Jianghuan
Department of Neurology, the Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou Province, China.
Neuroreport. 2025 Feb 5;36(3):127-134. doi: 10.1097/WNR.0000000000002128. Epub 2025 Jan 6.
We aimed to unveil the clinical significance of serum 25-hydroxyvitamin D (25-OH-VD), insulin-like growth factor 1 (IGF-1), and beta-2 microglobulin (β2-MG) levels in cognitive dysfunction after ischemic stroke (IS) in the elderly. A total of 160 geriatric IS patients admitted to our hospital were retrospectively collected. The patients' serum 25-OH-VD, IGF-1, and β2-MG levels were detected, and the correlation between the three levels and the patients' National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment (MoCA) scores was tested by the Pearson test. The diagnostic values of 25-OH-VD, IGF-1, and β2-MG for cognitive dysfunction and risk factors inducing cognitive dysfunction in the elderly after IS were evaluated. NIHSS score was negatively correlated with serum 25-OH-VD and IGF-1 levels, and positively correlated with serum β2-MG levels; MoCA score exhibited an inverse correlation. Diabetes, years of education <12 years, age, and serum high-sensitive C-reactive protein, cystatin C, 25-OH-VD, IGF-1, and β2-MG levels were independent factors for the development of cognitive dysfunction after IS in the elderly. The detection of 25-OH-VD, IGF-1, and β2-MG may be important for assessing the occurrence of cognitive dysfunction and the severity of the disease in patients.
我们旨在揭示老年缺血性卒中（IS）后认知功能障碍患者血清25-羟维生素D（25-OH-VD）、胰岛素样生长因子1（IGF-1）和β2微球蛋白（β2-MG）水平的临床意义。回顾性收集我院收治的160例老年IS患者。检测患者血清25-OH-VD、IGF-1和β2-MG水平，并通过Pearson检验分析三者水平与患者美国国立卫生研究院卒中量表（NIHSS）及蒙特利尔认知评估量表（MoCA）评分的相关性。评估25-OH-VD、IGF-1和β2-MG对老年IS后认知功能障碍的诊断价值及引发认知功能障碍的危险因素。NIHSS评分与血清25-OH-VD和IGF-1水平呈负相关，与血清β2-MG水平呈正相关；MoCA评分呈相反的相关性。糖尿病、受教育年限<12年、年龄以及血清高敏C反应蛋白、胱抑素C、25-OH-VD、IGF-1和β2-MG水平是老年IS后发生认知功能障碍的独立因素。检测25-OH-VD、IGF-1和β2-MG对于评估患者认知功能障碍的发生及疾病严重程度可能具有重要意义。
