Laboratory of Developmental Biology Research and Experimental Teratogenicity, The Children's Hospital of Mexico Federico Gómez (HIMFG), Dr. Márquez 162, Col. Doctores, Del. Cuauhtémoc, CP. 06720, Mexico City, CDMX, Mexico.
Postgraduate in Genomic Sciences, Autonomous University of Mexico City, Mexico City, Mexico.
Mol Biol Rep. 2022 Sep;49(9):8953-8973. doi: 10.1007/s11033-022-07385-2. Epub 2022 Apr 1.
Heart failure (HF) is a deeply serious clinical problem that remains unsolved. Many reports highlight the cardioprotective properties of mesenchymal stem cells (MSCs), the factors contained in their secretome being particularly important for this function; these include the exosomal miRNAs (exo-miRNAs) secreted with or without stimulus which can modulate various biological processes. In search of new paradigms in heart failure, we wondered whether MSC-derived exosomal microRNAs could play a role in the management of clinical patients.
To analyze whether there is sufficient evidence to support this hypothesis we designed a systematic review of studies on exo-miRNAs in heart diseases causing HF during the last decade.
The cardioprotective functions of twenty-four exo-miRNAs derived from bone marrow MSCs (BM-MSCs) are known and the functions of exo-miRNAs from other MSC sources such as adipose tissue, trophoblasts, amniotic fluid, and endometrium were also determined. Inhibition of apoptosis is the most reported biological function and the targets for thirty exo-miRNAs are known.
The results from this systematic review support the initial hypothesis and encourage us to test it in future experimental research works but more importantly, we seek to encourage other researchers in the field to propose other hypotheses aimed at the possible use of exo-miRNAs in HF secondary to cardiac disease.
心力衰竭（HF）是一个严重的临床问题，尚未得到解决。许多报告强调了间充质干细胞（MSCs）的心脏保护特性，其分泌组中的因子对于这种功能特别重要；其中包括在有或没有刺激的情况下分泌的外泌体 miRNAs（exo-miRNAs），它们可以调节各种生物过程。为了寻找心力衰竭的新范式，我们想知道 MSC 来源的外泌体 microRNAs 是否可以在临床患者的治疗中发挥作用。
为了分析是否有足够的证据支持这一假设，我们设计了一项关于过去十年中导致心力衰竭的心脏病中外泌体 miRNAs 的系统评价研究。
已知来源于骨髓 MSCs（BM-MSCs）的二十四种外泌体 microRNAs 的心脏保护功能，并且还确定了来源于其他 MSC 来源（如脂肪组织、滋养层、羊水和子宫内膜）的外泌体 microRNAs 的功能。抑制细胞凋亡是最常报道的生物学功能，已知有三十种外泌体 microRNAs 的靶标。
这项系统评价的结果支持最初的假设，并鼓励我们在未来的实验研究中进行测试，但更重要的是，我们希望鼓励该领域的其他研究人员提出其他假设，旨在探讨外泌体 microRNAs 在心脏疾病引起的心力衰竭中的可能应用。
